The roles and controls of GATA factors in blood and cardiac development

Tomasz Dobrzycki; Mukesh Lalwani; Caroline Telfer; Rui Monteiro; Roger Patient

doi:10.1002/iub.2178

The roles and controls of GATA factors in blood and cardiac development

IUBMB Life ◽

10.1002/iub.2178 ◽

2019 ◽

Vol 72 (1) ◽

pp. 39-44 ◽

Cited By ~ 2

Author(s):

Tomasz Dobrzycki ◽

Mukesh Lalwani ◽

Caroline Telfer ◽

Rui Monteiro ◽

Roger Patient

Keyword(s):

Cardiac Development ◽

Gata Factors

GATA factors in vertebrate heart development and disease

Expert Reviews in Molecular Medicine ◽

10.1017/s1462399406000093 ◽

2006 ◽

Vol 8 (22) ◽

pp. 1-20 ◽

Cited By ~ 82

Author(s):

Alison Brewer ◽

John Pizzey

Keyword(s):

Transcription Factors ◽

Heart Development ◽

Regulatory Networks ◽

Cardiac Development ◽

Cellular Mechanisms ◽

Cardiac Morphogenesis ◽

Functional Roles ◽

Gata Factors ◽

Evolutionarily Conserved ◽

Heart Formation

Vertebrate heart formation is dependent upon complex hierarchical gene regulatory networks, which effect both the specification and differentiation of cardiomyocytes and subsequently cardiac morphogenesis. GATA-4, -5 and -6 comprise an evolutionarily conserved subfamily of transcription factors, which are expressed within the precardiac mesoderm from early stages in its specification and continue to be expressed within the adult heart. We review here the functional roles of individual GATA transcription factors in cardiac development, normal homeostasis and disease. We also review the cellular mechanisms employed to regulate the expression and downstream targets of the different GATA factors.

Angiotensin2-receptors in postnatal cardiac development

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0029-1191418 ◽

2009 ◽

Vol 56 (S 01) ◽

Author(s):

D Biermann ◽

L Conradi ◽

H Treede ◽

A Heimann ◽

M Didié ◽

...

Keyword(s):

Cardiac Development

Understanding Cardiac Development Through the Perspective of Gene Regulation and Gene Manipulation

Fetal and Pediatric Pathology ◽

10.3109/15513819609169282 ◽

1996 ◽

Vol 16 (2) ◽

pp. 173-194

Author(s):

David Witte ◽

Bruce Aronow ◽

Judith Harmony

Keyword(s):

Gene Regulation ◽

Cardiac Development ◽

Gene Manipulation

Faculty Opinions recommendation of Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1015088.195801 ◽

2003 ◽

Author(s):

Ranjan Sen

Keyword(s):

B Cell ◽

Type B ◽

Wild Type ◽

Myeloid Lineage ◽

Gata Factors ◽

Lineage Switch

Faculty Opinions recommendation of A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022645.259645 ◽

2004 ◽

Author(s):

Peter Scambler

Keyword(s):

Cardiac Development ◽

Null Mutation

Faculty Opinions recommendation of Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1027852.335815 ◽

2005 ◽

Author(s):

Paul Webb

Keyword(s):

Breast Cancer ◽

Protein Kinase ◽

Protein Kinase A ◽

Cancer Cells ◽

Nuclear Receptor ◽

Breast Cancer Cells ◽

Promoter Activity ◽

Gata Factors ◽

Human Aromatase ◽

Kinase A

Faculty Opinions recommendation of Heterogeneity of genetic modifiers ensures normal cardiac development.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4425957.4221089 ◽

2010 ◽

Author(s):

David Brook ◽

Javier T Granados-Riveron

Keyword(s):

Cardiac Development ◽

Genetic Modifiers

Faculty of 1000 evaluation for MED GATA factors promote robust development of the C. elegans endoderm.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.725484309.793506953 ◽

2015 ◽

Author(s):

Ryan Baugh

Keyword(s):

C Elegans ◽

Gata Factors

Faculty Opinions recommendation of Cilia, mitochondria, and cardiac development.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736004863.793565297 ◽

2019 ◽

Author(s):

Michael Klymkowsky

Keyword(s):

Cardiac Development

Regulatory Mechanisms of Cardiac Development and Repair

Cardiovascular & Haematological Disorders - Drug Targets ◽

10.2174/187152906777441849 ◽

2006 ◽

Vol 6 (2) ◽

pp. 99-110 ◽

Cited By ~ 7

Author(s):

Ana Chinchilla ◽

Diego Franco

Keyword(s):

Cardiac Development ◽

Regulatory Mechanisms