Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization

IUBMB Life ◽  
2020 ◽  
Vol 72 (11) ◽  
pp. 2409-2419
Author(s):  
Hao Hu ◽  
Jiawei Wu ◽  
Cheng Cao ◽  
Likun Ma
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cells ◽  
Regulatory T Cells ◽  
M2 Polarization

scholarly journals Circulating Th17 and Tc17 Cells and Their Imbalance with Regulatory T Cells Is Associated with Myocardial Infarction in Young Indian Patients

2015 ◽  
Vol 05 (12) ◽  
pp. 373-387 ◽  
Author(s):  
Thiruvelselvan Ponnusamy ◽  
Komarlu Venkatachala Srikanth ◽  
Ramanjappa Manjunatha ◽  
Vijay V. Kakkar ◽  
Lakshmi Mundkur
Keyword(s):  
Myocardial Infarction ◽  
T Cells ◽  
Regulatory T Cells ◽  
Indian Patients ◽  
Tc17 Cells

scholarly journals Peripheral Levels of EPCs, T Cells, and Macrophages’ as Possible Predictive Biomarkers of Acute Myocardial Infarction

2020 ◽  
Author(s):  
Amankeldi Salybekov ◽  
Katsuaki Sakai ◽  
Makoto Natsumeda ◽  
Kosit Vorateera ◽  
Shuzo Kobayashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cells ◽  
Cd8 T Cells ◽  
Immune Cell ◽  
Temporal Dynamics ◽  
Predictive Biomarkers ◽  
Mortality And Morbidity ◽  
Patients With Diabetes ◽  
Functionally Impaired

Abstract Acute myocardial infarction (AMI), with a very relevant global disease burden, remains the major mortality and morbidity cause among all cardiovascular diseases. Patient prognosis is strictly dependent on early diagnosis and the adoption of adequate interventions. AMI diagnosis requires constant optimization, particularly considering the individuals at higher risk (or more vulnerable to worse outcomes) such as patients with diabetes mellitus and atherosclerosis. Herein, we investigated the levels of peripheral blood EPCs and immune cell-subsets from myeloid and lymphoid lineages, as well as their temporal dynamics, in the quest for new prognostic biomarkers of AMI. We collected blood from 18 hospitalized patients (days 3 and 7 after AMI onset) and 16 healthy volunteers, and resolved their circulating PBMC populations via flow cytometry. Overall, our data demonstrate a significant decrease in peripheral EPCs and CD8+ T cells, three days following an AMI. EPCs appear to be functionally impaired in AMI patients, and their circulating numbers associate with cardiac vessel lesions. Furthermore, CD8+ T cells (and even M1-macrophages) in the periphery, in combination with the classical laboratory determinations, may serve as high accuracy biomarkers of AMI, potentially aiding to prevent worse AMI outcomes.

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

2011 ◽  
Vol 107 (1) ◽  
Author(s):  
Ting-Ting Tang ◽  
Jing Yuan ◽  
Zheng-Feng Zhu ◽  
Wen-Cai Zhang ◽  
Hong Xiao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
T Cells ◽  
Regulatory T Cells ◽  
Cardiac Remodeling

Frequency of naturally-occurring regulatory T cells is reduced in patients with ST-segment elevation myocardial infarction

2007 ◽  
Vol 120 (4) ◽  
pp. 631-634 ◽  
Author(s):  
Gennaro Sardella ◽  
Leonardo De Luca ◽  
Vittorio Francavilla ◽  
Daniele Accapezzato ◽  
Massimo Mancone ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
T Cells ◽  
Regulatory T Cells ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
Naturally Occurring ◽  
St Segment

Potential role of invariant natural killer T cells in outcomes of acute myocardial infarction

2015 ◽  
Vol 187 ◽  
pp. 663-665 ◽  
Author(s):  
Jan Novak ◽  
Jan Dobrovolny ◽  
Petr Tousek ◽  
Viktor Kocka ◽  
Elena Teringova ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cells ◽  
Natural Killer ◽  
Potential Role ◽  
Natural Killer T Cells ◽  
Killer T Cells ◽  
Invariant Natural Killer ◽  
Natural Killer T
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