Sensitive multiplex detection of serological liver cancer biomarkers using SERS-active photonic crystal fiber probe

A high-efficiency coupling method using the gradient-index (GRIN) fiber probe and hollow-core photonic crystal fiber (HC-PCF) is proposed to improve the response time and the sensitivity of gas sensors. A coupling efficiency model of the GRIN fiber probe coupled with HC-PCF is analyzed. An optimization method is proposed to guide the design of the probe and five samples of the GRIN fiber probe with different performances are designed, fabricated, and measured. Next, a coupling efficiency experimental system is established. The coupling efficiencies of the probes and single-mode fiber (SMF) are measured and compared. The experimental results corrected by image processing show that the GRIN fiber probe can achieve a coupling efficiency of 80.22% at distances up to 180 μm, which is obviously superior to the value of 33.45% of SMF at the same distance. Moreover, with the increase of the coupling distance, the coupling efficiency of the probe is still higher than that of SMF.

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Development of highly reliable SERS‐active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid

Journal of Biophotonics ◽

10.1002/jbio.201960120 ◽

2019 ◽

Vol 13 (3) ◽

Cited By ~ 2

Author(s):

Flavien Beffara ◽

Jayakumar Perumal ◽

Aniza Puteri Mahyuddin ◽

Mahesh Choolani ◽

Saif A. Khan ◽

...

Keyword(s):

Ovarian Cancer ◽

Photonic Crystal ◽

Photonic Crystal Fiber ◽

Cancer Biomarker ◽

Cyst Fluid ◽

Fiber Probe ◽

Crystal Fiber

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Hollow-core photonic crystal fiber probe for remote fluorescence sensing with single molecule sensitivity

Optics Express ◽

10.1364/oe.20.028379 ◽

2012 ◽

Vol 20 (27) ◽

pp. 28379 ◽

Cited By ~ 13

Author(s):

Petru Ghenuche ◽

Hervé Rigneault ◽

Jérôme Wenger

Keyword(s):

Photonic Crystal ◽

Photonic Crystal Fiber ◽

Single Molecule ◽

Hollow Core ◽

Fluorescence Sensing ◽

Fiber Probe ◽

Crystal Fiber

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Kagome hollow-core photonic crystal fiber probe for Raman spectroscopy

Optics Letters ◽

10.1364/ol.37.004371 ◽

2012 ◽

Vol 37 (21) ◽

pp. 4371 ◽

Cited By ~ 41

Author(s):

Petru Ghenuche ◽

Silke Rammler ◽

Nicolas Y. Joly ◽

Michael Scharrer ◽

Michael Frosz ◽

...

Keyword(s):

Raman Spectroscopy ◽

Photonic Crystal ◽

Photonic Crystal Fiber ◽

Hollow Core ◽

Fiber Probe ◽

Crystal Fiber

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Enhanced Artificial Intelligent Method for Representing the Photonic Crystal Fiber Profile Index

Al-Kitab Journal for Pure Sciences ◽

10.32441/kjps.v1i1.87 ◽

2018 ◽

Vol 1 (1) ◽

pp. 2-19

Author(s):

Mahmood Sh. Majeed ◽

Raid W. Daoud

Keyword(s):

Genetic Algorithms ◽

Photonic Crystal ◽

Photonic Crystal Fiber ◽

New Method ◽

Proper Solution ◽

Artificial Intelligent ◽

Crystal Fiber ◽

Fitness Value ◽

First Pass ◽

Crossover And Mutation

A new method proposed in this paper to compute the fitness in Genetic Algorithms (GAs). In this new method the number of regions, which assigned for the population, divides the time. The fitness computation here differ from the previous methods, by compute it for each portion of the population as first pass, then the second pass begin to compute the fitness for population that lye in the portion which have bigger fitness value. The crossover and mutation and other GAs operator will do its work only for biggest fitness portion of the population. In this method, we can get a suitable and accurate group of proper solution for indexed profile of the photonic crystal fiber (PCF).

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