Comparative study of the viscoelastic mechanical behavior of agarose and poly(ethylene glycol) hydrogels

2011 ◽  
Vol 99B (1) ◽  
pp. 158-169 ◽  
Author(s):  
Justine J. Roberts ◽  
Audrey Earnshaw ◽  
Virginia L. Ferguson ◽  
Stephanie J. Bryant
Author(s):  
Francesca Della Sala ◽  
Marco Biondi ◽  
Daniela Guarnieri ◽  
Assunta Borzacchiello ◽  
Luigi Ambrosio ◽  
...  

Author(s):  
Audrey L. Earnshaw ◽  
Justine J. Roberts ◽  
Garret D. Nicodemus ◽  
Stephanie J. Bryant ◽  
Virginia L. Ferguson

Agarose and poly(ethylene-glycol) (PEG) are commonly used as scaffolds for cell and tissue engineering applications [1]. Agarose is a natural biomaterial that is thought to be inert [2] and permits growing cells and tissues in a three-dimensional suspension [3]. Gels synthesized from photoreactive poly(ethylene glycol) (PEG) macromonomers are well suited as cell carriers because they can be rapidly photopolymerized in vivo by a chain radical polymerization that is not toxic to cells, including chondrocytes. This paper explores the differences in mechanical behavior between agarose, a physically cross-linked hydrogel, and PEG, a chemically cross-linked hydrogel, to set the foundation for choosing hydrogel properties and chemistries for a desired tissue engineering application.


2017 ◽  
Vol 13 ◽  
pp. 19-25 ◽  
Author(s):  
Andrea Mascitti ◽  
Massimiliano Lupacchini ◽  
Ruben Guerra ◽  
Ilya Taydakov ◽  
Lucia Tonucci ◽  
...  

The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.


2019 ◽  
Vol 52 (1) ◽  
pp. 165-178 ◽  
Author(s):  
Philipp Bohn ◽  
Michael A. R. Meier

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