Self-Assembled Monothiol-Terminated Hyperbranched Polyglycerols on a Gold Surface:  A Comparative Study on the Structure, Morphology, and Protein Adsorption Characteristics with Linear Poly(ethylene glycol)s

Langmuir ◽  
2008 ◽  
Vol 24 (9) ◽  
pp. 4907-4916 ◽  
Author(s):  
Rajesh K. Kainthan ◽  
Yuquan Zou ◽  
Mu Chiao ◽  
Jayachandran N. Kizhakkedathu
Keyword(s):  
Ethylene Glycol ◽  
Comparative Study ◽  
Protein Adsorption ◽  
Gold Surface ◽  
Poly Ethylene Glycol ◽  
Adsorption Characteristics ◽  
Structure Morphology ◽  
Linear Poly ◽  
Self Assembled ◽  
Poly Ethylene

Measurements of Interbilayer Forces and Protein Adsorption on Uncharged Lipid Bilayers Displaying Poly(ethylene glycol) Chains†

Biochemistry ◽  
2000 ◽  
Vol 39 (12) ◽  
pp. 3441-3451 ◽  
Author(s):  
Nadezhda V. Efremova ◽  
Bruce Bondurant ◽  
David F. O'Brie ◽  
Deborah E. Leckband
Keyword(s):  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Lipid Bilayers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol) Grafting to Poly(ether imide) Membranes: Influence on Protein Adsorption and Thrombocyte Adhesion

2013 ◽  
Vol 13 (12) ◽  
pp. 1720-1729 ◽  
Author(s):  
Axel T. Neffe ◽  
Maik von Ruesten-Lange ◽  
Steffen Braune ◽  
Karola Luetzow ◽  
Toralf Roch ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol) Self-Assembled Monolayer Island Growth

Langmuir ◽  
2005 ◽  
Vol 21 (7) ◽  
pp. 2981-2987 ◽  
Author(s):  
Jonas Rundqvist ◽  
Jan H. Hoh ◽  
David B. Haviland
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Island Growth ◽  
Self Assembled Monolayer ◽  
Self Assembled ◽  
Poly Ethylene

scholarly journals Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

2019 ◽  
Vol 5 (2) ◽  
pp. eaav9322 ◽  
Author(s):  
Dali Wang ◽  
Jiaqi Lin ◽  
Fei Jia ◽  
Xuyu Tan ◽  
Yuyan Wang ◽  
...  
Keyword(s):  
Rna Interference ◽  
Ethylene Glycol ◽  
Target Genes ◽  
Area Under The Curve ◽  
Fold Increase ◽  
Small Interfering Rnas ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene

Nonhepatic delivery of small interfering RNAs (siRNAs) remains a challenge for development of RNA interference–based therapeutics. We report a noncationic vector wherein linear poly(ethylene glycol) (PEG), a polymer generally considered as inert and safe biologically but ineffective as a vector, is transformed into a bottlebrush architecture. This topology provides covalently embedded siRNA with augmented nuclease stability and cellular uptake. Consisting almost entirely of PEG and siRNA, the conjugates exhibit a ~25-fold increase in blood elimination half-life and a ~19-fold increase in the area under the curve compared with unmodified siRNA. The improved pharmacokinetics results in greater tumor uptake and diminished liver capture. Despite the structural simplicity these conjugates efficiently knock down target genes in vivo without apparent toxic and immunogenic reactions. Given the benign biological nature of PEG and its widespread precedence in biopharmaceuticals, we anticipate the brush polymer–based technology to have a significant impact on siRNA therapeutics.

Fluorescence Microscopy Study of Protein Adsorption at Modified Glassy Carbon Surfaces

2005 ◽  
Vol 58 (4) ◽  
pp. 275 ◽  
Author(s):  
Alison J. Downard ◽  
Sandra L. Jackson ◽  
Emelyn S. Q. Tan
Keyword(s):  
Fluorescence Microscopy ◽  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Glassy Carbon ◽  
Direct Method ◽  
Primary Amines ◽  
Tetraethylene Glycol ◽  
Surface Films ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Glassy carbon (GC) surfaces were modified with thin films by means of electrochemically assisted reduction of aryl diazonium salts and oxidation of primary amines. GC plates with modified and unmodified areas were exposed to solutions of fluorescently labelled bovine serum albumin (BSA-FITC). Fluorescence microscopy was found to be a simple and direct method for comparing adsorption of BSA-FITC between the different areas. Modification with methylbenzene, hexylbenzene, poly(ethylene glycol) benzene, and tetraethylene glycol diamine groups increases protein adsorption relative to unmodified GC. Hexylamine and the poly(ethylene glycol) diamine ED-2003 reduce protein adsorption. The results give insight into some factors controlling protein adsorption at these surface films.

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