Decision letter for "Glutamine metabolism in osteoprogenitors is required for bone mass accrual and PTH ‐induced bone anabolism in male mice"

2020 ◽  
Keyword(s):  
Bone Mass ◽  
Glutamine Metabolism ◽  
Male Mice ◽  
Bone Mass Accrual

scholarly journals Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH ‐Induced Bone Anabolism in Male Mice

2020 ◽  
Author(s):  
Steve Stegen ◽  
Claire‐Sophie Devignes ◽  
Sophie Torrekens ◽  
Riet Van Looveren ◽  
Peter Carmeliet ◽  
...  
Keyword(s):  
Bone Mass ◽  
Glutamine Metabolism ◽  
Male Mice ◽  
Bone Mass Accrual

scholarly journals Glutamine metabolism in osteoprogenitors governs bone mass accrual and PTH-induced bone anabolism

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100661
Author(s):  
Steve Stegen ◽  
Sophie Torrekens ◽  
Riet Van Looveren ◽  
Peter Carmeliet ◽  
Geert Carmeliet
Keyword(s):  
Bone Mass ◽  
Glutamine Metabolism ◽  
Bone Mass Accrual

Influence of pubertal development and body composition on bone mass accrual in apparently healthy school children aged 6-17 years

2015 ◽  
Author(s):  
Aashima Dabas ◽  
Rajesh Khadgawat ◽  
R K Marwaha ◽  
N Mehan ◽  
A Sastry ◽  
...  
Keyword(s):  
Body Composition ◽  
Bone Mass ◽  
School Children ◽  
Pubertal Development ◽  
Bone Mass Accrual ◽  
Apparently Healthy

Bone mass accrual following supplementation of vitamin D alone versus vitamin D+ calcium in underprivileged Indian premenarcheal girls

2013 ◽  
Author(s):  
Sunil Kumar Kota ◽  
Lalit Kumar Meher ◽  
Sruti Jammula ◽  
Kirtikumar D Modi
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Bone Mass Accrual

The Effect of Hormonal Oral Contraception on Acquisition of Peak Bone Mineral Density of Adolescents and Young Women

2012 ◽  
Vol 25 (3) ◽  
pp. 331-340 ◽  
Author(s):  
Susan Ziglar ◽  
Tracy S. Hunter
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Young Women ◽  
Bone Mineralization ◽  
Critical Time ◽  
Health Concern ◽  
Mineral Density ◽  
Peak Bone Mineral Density ◽  
Bone Mass Accrual

Maximizing bone mass in youth is touted as the best strategy to offset the natural losses of aging and the menopausal transition. Not achieving maximum peak bone mineral density (BMD) is an independent risk factor for osteoporosis and thus a public health concern. Adolescence is a critical time of bone mineralization mediated by endogenous estradiol. Research has shown that the highest velocity of bone mass accrual occurs 1 year before menarche and after the first 3 years. Low-peak attainment of BMD in young women is associated with contributing factors such as diets low in calcium, eating disorders, lack of exercise, smoking, and low estrogen states. Oral contraceptives (OCs) suppress endogenous estradiol production by suppressing the hypothalamic–pituitary–ovarian axis. Thus, OCs, by replacing endogenous estradiol with ethinyl estradiol (EE), establish and maintain new hormone levels. The early initiation and the use of very low dose of EE raises the possibility that bone mass accrual at a critical time of bone mineralization in young women or adolescents may be jeopardized. This review examines the studies of BMD in adolescents and young women that use combination hormonal contraception. Some studies had inherent limitations, such as small trial, poor control of confounders, failure to exclude women with prior use of hormonal contraceptives, or prior pregnancy from control groups. The vast majority of reviewed studies showed OCs containing 20 to 30 µg of EE interfere with acquisition of peak BMD. Limited numbers of studies examine the effects of OCs containing 35 µg on adolescents and young adults. Additionally, studies are needed evaluating the progestin component of OCs as their differing androgenic properties may affect bone mineralization as well.

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