Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis

2009 ◽  
Vol 3 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Joseph A. Lorenzo ◽  
Sandra Sousa
Keyword(s):  
Bone Resorption ◽  
Phorbol Esters ◽  
Prostaglandin Synthesis ◽  
Long Bone ◽  
Stimulate Bone Resorption ◽  
Fetal Rat ◽  
Bone Cultures

Leukemia inhibitory factor (LIF) inhibits basal bone resorption in fetal rat long bone cultures

Cytokine ◽  
1990 ◽  
Vol 2 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Joseph A. Lorenzo ◽  
Sandra L. Sousa ◽  
Christina L. Leahy
Keyword(s):  
Bone Resorption ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Long Bone ◽  
Basal Bone ◽  
Fetal Rat ◽  
Bone Cultures

Interleukin 6 production in fetal rat long bone cultures is correlated with PGE2 release and does not correlate with the extent of bone resorption

Cytokine ◽  
1994 ◽  
Vol 6 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Donald R. Bertolini ◽  
Bartholomew Votta ◽  
Sandra Hoffman ◽  
Gideon Strassmann
Keyword(s):  
Bone Resorption ◽  
Interleukin 6 ◽  
Long Bone ◽  
Fetal Rat ◽  
Pge2 Release ◽  
Bone Cultures

scholarly journals Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis.

1981 ◽  
Vol 154 (2) ◽  
pp. 529-534 ◽  
Author(s):  
R S Bockman ◽  
M A Repo
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Bone Loss ◽  
Inflammatory Cell ◽  
Prostaglandin Synthesis ◽  
Conditioned Media ◽  
Local Production ◽  
Endogenous Prostaglandin ◽  
Rapid Release ◽  
Fetal Rat

Enhanced synthesis of prostaglandin (PG) E by explanted fetal rat bones was initiated by lymphocyte-conditioned media but not by physiological levels of parathyroid hormone. Rapid release of PGE from bone occurred only when the lymphokine was present. Synthesis of PGE preceded and was necessary for the bone resorption caused by the lymphokine preparation. Local production of prostaglandins in response to inflammatory cell or tumor-derived factors may in part be responsible for the localized bone loss that occurs in certain pathological states.

Leukemia inhibitory factor inhibits resorption in fetal rat long bone cultures

1990 ◽  
Vol 10 (3) ◽  
pp. S267-S268
Author(s):  
Joseph Lorenzo ◽  
Christina Leahy ◽  
Sandra Sousa
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Long Bone ◽  
Fetal Rat ◽  
Bone Cultures
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