Leukemia inhibitory factor (LIF) inhibits basal bone resorption in fetal rat long bone cultures

Cytokine ◽  
1990 ◽  
Vol 2 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Joseph A. Lorenzo ◽  
Sandra L. Sousa ◽  
Christina L. Leahy
Keyword(s):  
Bone Resorption ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Long Bone ◽  
Basal Bone ◽  
Fetal Rat ◽  
Bone Cultures

Leukemia inhibitory factor inhibits resorption in fetal rat long bone cultures

1990 ◽  
Vol 10 (3) ◽  
pp. S267-S268
Author(s):  
Joseph Lorenzo ◽  
Christina Leahy ◽  
Sandra Sousa
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Long Bone ◽  
Fetal Rat ◽  
Bone Cultures

Interleukin 6 production in fetal rat long bone cultures is correlated with PGE2 release and does not correlate with the extent of bone resorption

Cytokine ◽  
1994 ◽  
Vol 6 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Donald R. Bertolini ◽  
Bartholomew Votta ◽  
Sandra Hoffman ◽  
Gideon Strassmann
Keyword(s):  
Bone Resorption ◽  
Interleukin 6 ◽  
Long Bone ◽  
Fetal Rat ◽  
Pge2 Release ◽  
Bone Cultures

scholarly journals Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts

1999 ◽  
Vol 276 (3) ◽  
pp. E465-E471
Author(s):  
Samuel Varghese ◽  
Kyung Yu ◽  
Ernesto Canalis
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Collagen Synthesis ◽  
Oncostatin M ◽  
Inhibitory Factor ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Dependent Manner ◽  
Gelatinase A ◽  
Protein Levels ◽  
Fetal Rat ◽  
Dose Dependent

Leukemia inhibitory factor (LIF) and oncostatin M (OSM) have multiple effects on skeletal remodeling. Although these cytokines modestly regulate collagen synthesis in osteoblasts, their effects on collagenase expression and collagen degradation are not known. We tested whether LIF and OSM regulate the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in osteoblast-enriched cells isolated from fetal rat calvariae. LIF and OSM increased collagenase-3 (MMP-13) mRNA and immunoreactive protein levels in a time- and dose-dependent manner. LIF and OSM enhanced the rate of transcription of the collagenase gene and stabilized collagenase mRNA in transcriptionally arrested cells. LIF and OSM failed to regulate the expression of gelatinase A (MMP-2) and B (MMP-9). LIF and OSM modestly stimulated the expression of TIMP-1 but did not alter the expression of TIMP-2 and -3. In conclusion, LIF and OSM stimulate collagenase-3 and TIMP-1 expression in osteoblasts, and these effects may be involved in mediating the bone remodeling actions of these cytokines.

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