Vitexin prevents Aβ proteotoxicity in transgenic Caenorhabditis elegans model of Alzheimer's disease by modulating unfolded protein response

2020 ◽  
Author(s):  
Dicson Sheeja Malar ◽  
Mani Iyer Prasanth ◽  
Mahalingam Jeyakumar ◽  
Krishnaswamy Balamurugan ◽  
Kasi Pandima Devi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Model Of Alzheimer’S Disease ◽  
Protein Response

scholarly journals Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Priyanka Joshi ◽  
Michele Perni ◽  
Ryan Limbocker ◽  
Benedetta Mannini ◽  
Sam Casford ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Neurodegenerative Disorders ◽  
C Elegans ◽  
Unfolded Protein ◽  
Model Of Alzheimer’S Disease ◽  
Age Related ◽  
Parkinson’S Diseases ◽  
Protein Response

AbstractAge-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Although the roles of metabolites have been extensively studied with regard to cellular signaling pathways, their effects on protein aggregation remain relatively unexplored. By computationally analysing the Human Metabolome Database, we identified two endogenous metabolites, carnosine and kynurenic acid, that inhibit the aggregation of the amyloid beta peptide (Aβ) and rescue a C. elegans model of Alzheimer’s disease. We found that these metabolites act by triggering a cytosolic unfolded protein response through the transcription factor HSF-1 and downstream chaperones HSP40/J-proteins DNJ-12 and DNJ-19. These results help rationalise previous observations regarding the possible anti-ageing benefits of these metabolites by providing a mechanism for their action. Taken together, our findings provide a link between metabolite homeostasis and protein homeostasis, which could inspire preventative interventions against neurodegenerative disorders.

scholarly journals Rab6 is a Modulator of the Unfolded Protein Response: Implications for Alzheimer's Disease

2012 ◽  
Vol 28 (4) ◽  
pp. 917-929 ◽  
Author(s):  
Hyung Lim Elfrink ◽  
Rob Zwart ◽  
María L. Cavanillas ◽  
Adam Jay Schindler ◽  
Frank Baas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals The unfolded protein response is activated in the olfactory system in Alzheimer’s disease

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Helen C. Murray ◽  
Birger Victor Dieriks ◽  
Molly E. V. Swanson ◽  
Praju Vikas Anekal ◽  
Clinton Turner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Olfactory System ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

The Unfolded Protein Response Is Involved in the Pathology of Alzheimer's Disease

2002 ◽  
Vol 977 (1) ◽  
pp. 349-355 ◽  
Author(s):  
TAKASHI KUDO ◽  
TAIICHI KATAYAMA ◽  
KAZUNORI IMAIZUMI ◽  
YUKA YASUDA ◽  
MISAKO YATERA ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response
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