Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

1994 ◽  
Vol 55 (1) ◽  
pp. 106-119 ◽  
Author(s):  
Thomas R. Polte ◽  
Steven K. Hanks ◽  
Allen J. Naftilan
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Focal Adhesion Kinase ◽  
Blood Vessels ◽  
Vascular Smooth Muscle Cells ◽  
Focal Adhesion ◽  
Muscle Cells ◽  
Rapid Response

Resveratrol inhibits glucose‐induced migration of vascular smooth muscle cells mediated by focal adhesion kinase

2014 ◽  
Vol 58 (7) ◽  
pp. 1389-1401 ◽  
Author(s):  
Yi‐Chiao Lin ◽  
Li‐Hsuen Chen ◽  
T. Varadharajan ◽  
May‐Jywan Tsai ◽  
Yi‐Chen Chia ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Focal Adhesion Kinase ◽  
Vascular Smooth Muscle Cells ◽  
Focal Adhesion ◽  
Muscle Cells

scholarly journals FRNK Inhibition of Focal Adhesion Kinase–Dependent Signaling and Migration in Vascular Smooth Muscle Cells

2010 ◽  
Vol 30 (11) ◽  
pp. 2226-2233 ◽  
Author(s):  
Yevgeniya E. Koshman ◽  
Taehoon Kim ◽  
Miensheng Chu ◽  
Steven J. Engman ◽  
Rekha Iyengar ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Focal Adhesion Kinase ◽  
Vascular Smooth Muscle Cells ◽  
Focal Adhesion ◽  
Muscle Cells ◽  
And Migration

Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress

2007 ◽  
Vol 293 (4) ◽  
pp. H2085-H2092 ◽  
Author(s):  
Yifan Chen ◽  
Adam Pearlman ◽  
Zaiming Luo ◽  
Christopher S. Wilcox
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Blood Vessels ◽  
Vascular Smooth Muscle Cells ◽  
Prolonged Exposure ◽  
Muscle Cells ◽  
Mesenteric Arteries

Tempol catalyzes the formation of H2O2 from superoxide and relaxes blood vessels. We tested the hypothesis that the generation of H2O2 by tempol in vascular smooth muscle cells during oxidative stress contributes to the vasorelaxation. Tempol and nitroblue tetrazolium (NBT) both metabolize superoxide in vascular smooth muscle cells, but only tempol generates H2O2. Rat pressurized mesenteric arteries were exposed for 20 min to the thromboxane-prostanoid receptor agonist, U-46619, or norepinephrine. During U-46619, tempol caused a transient dilation (22 ± 2%), whereas NBT was ineffective (2 ± 1%), and neither dilated vessels constricted with norepinephrine, which does not cause vascular oxidative stress. Neither endothelium removal nor blockade of K+ channels with 40 mM KCl affected the tempol-induced dilation, but catalase blunted the tempol dilation by 53 ± 7%. Tempol, but not NBT, increased H2O2 in rat mesenteric vessels detected with dichlorofluorescein. To test physiological relevance in vivo, topical application of tempol caused a transient dilation (184 ± 20%) of mouse cremaster arterioles exposed to angiotensin II for 30 min, which was not seen with NBT (9 ± 4%). The vasodilation to tempol was reduced by 68 ± 6% by catalase. We conclude that the transient relaxation of blood vessels by tempol after prolonged exposure to U-46619 or angiotensin II is mediated in part via production of H2O2 and is largely independent of the endothelium and potassium channels.

scholarly journals Thrombospondin-1 induces activation of focal adhesion kinase in vascular smooth muscle cells

1999 ◽  
Vol 29 (6) ◽  
pp. 1031-1036 ◽  
Author(s):  
Vivian Gahtan ◽  
Xiu-Jie Wang ◽  
Masataka Ikeda ◽  
Alliric I. Willis ◽  
George P. Tuszynski ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Focal Adhesion Kinase ◽  
Vascular Smooth Muscle Cells ◽  
Focal Adhesion ◽  
Muscle Cells ◽  
Thrombospondin 1
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