Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells

2016 ◽  
Vol 117 (12) ◽  
pp. 2875-2885 ◽  
Author(s):  
Josiane Semaan ◽  
Aline Pinon ◽  
Benjamin Rioux ◽  
Lama Hassan ◽  
Youness Limami ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
Cox 2 ◽  
Induced Apoptosis ◽  
Ht 29

scholarly journals miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

2020 ◽  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
P53 Expression ◽  
Colorectal Cancer Cells ◽  
Scratch Wound ◽  
And Migration ◽  
Induced Apoptosis ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells were treated with DOX. Cell viability, apoptosis, and migration were evaluated by MTT, flow cytometry, and scratch-wound motility assays, respectively. Furthermore, the expression level of miR-214 and p53 was evaluated by qRT-PCR. Results: miR-214 transfection significantly inhibited the cell proliferation rate (P<0.05), induced apoptosis (P<0.05), and harnessed migration (P<0.05) in the HT-29 cells after 48 h. Furthermore, more effectiveness was observed in combination with DOX. Additionally, miR-214 transfection led to a reduction in p53 expression offering that it might be a potential target for miR-214. Conclusion: In conclusion, miR-214 sensitizes HT-29 cells to doxorubicin by targeting p53 indicating the significant role of this miRNA in colorectal cancer chemotherapy.

HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells

Inflammation ◽  
2016 ◽  
Author(s):  
A. Mohammadi ◽  
M.M. Yaghoobi ◽  
A. Gholamhoseinian Najar ◽  
B. Kalantari-Khandani ◽  
H. Sharifi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Pge2 Production ◽  
Hsp90 Inhibition ◽  
Colorectal Cancer Cells ◽  
Cox 2 ◽  
Ht 29

scholarly journals Poly-γ-Glutamic Acid Induces Apoptosis via Reduction of COX-2 Expression in TPA-Induced HT-29 Human Colorectal Cancer Cells

2015 ◽  
Vol 16 (12) ◽  
pp. 7577-7586 ◽  
Author(s):  
Eun Shin ◽  
Mi Sung ◽  
Jae Park ◽  
Hye Yang ◽  
Myung Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Glutamic Acid ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Cox 2 ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death

Biochimie ◽  
2011 ◽  
Vol 93 (4) ◽  
pp. 749-757 ◽  
Author(s):  
Youness Limami ◽  
Aline Pinon ◽  
David Yannick Leger ◽  
Yoanne Mousseau ◽  
Jeanne Cook-Moreau ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Colorectal Cancer Cells ◽  
Cox 2 ◽  
Ht 29

COX-2/PGE2 regulates VEGF expression by activating Wnt/β-catenin signal pathway in human colorectal cancer cells

2013 ◽  
Vol 32 (11) ◽  
pp. 1178-1181
Author(s):  
Xuan LIU ◽  
Dan-guang LI ◽  
Li-hong ZHOU ◽  
Yan WANG ◽  
Pei-hao YIN ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signal Pathway ◽  
Human Colorectal Cancer ◽  
Vegf Expression ◽  
Colorectal Cancer Cells ◽  
Cox 2 ◽  
Human Colorectal Cancer Cells

scholarly journals Correction to: Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells

2021 ◽  
Author(s):  
Golnaz Rashidi ◽  
Mahsa Rezaeepoor ◽  
Chiman Mohammadi ◽  
Ghasem Solgi ◽  
Rezvan Najafi
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Semaphorin 4D ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis

Effect of the polysaccharides derived from Dendrobium officinale stems on human HT-29 colorectal cancer cells and a zebrafish model

2021 ◽  
pp. 100995
Author(s):  
Shengchang Tao ◽  
Chunlei Huang ◽  
Zhihong Tan ◽  
Shuna Duan ◽  
Xiaofeng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Dendrobium Officinale ◽  
Zebrafish Model ◽  
Colorectal Cancer Cells ◽  
Ht 29

A novel natural tautomeric pair of garcinielliptone FC suppressed nuclear factor κB and induced apoptosis in human colorectal cancer cells

2016 ◽  
Vol 24 ◽  
pp. 568-578 ◽  
Author(s):  
Shen-Jeu Won ◽  
Ting-Yu Lin ◽  
Cheng-Hsin Yen ◽  
Yu-Hau Tzeng ◽  
Hsiao-Sheng Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis ◽  
Human Colorectal Cancer Cells

scholarly journals The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yasamin Dabiri ◽  
Sara Kalman ◽  
Clara-Marie Gürth ◽  
Jee Young Kim ◽  
Viola Mayer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Essential Role ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis

Crataegus azarolusLeaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells

2015 ◽  
Vol 117 (5) ◽  
pp. 1262-1272 ◽  
Author(s):  
Nadia Mustapha ◽  
Aline Pinon ◽  
Youness Limami ◽  
Alain Simon ◽  
Kamel Ghedira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
Hct 116 ◽  
Ht 29
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