Aspartate-β-semialdeyhyde dehydrogenase as a potential therapeutic target ofMycobacterium tuberculosisH37Rv: Evidence from in silico elementary mode analysis of biological network model

2017 ◽  
Vol 119 (3) ◽  
pp. 2832-2842 ◽  
Author(s):  
Saif Khan ◽  
Pallavi Somvanshi ◽  
Tulika Bhardwaj ◽  
Raju K. Mandal ◽  
Sajad A. Dar ◽  
...  
Keyword(s):  
Network Model ◽  
Therapeutic Target ◽  
In Silico ◽  
Biological Network ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Potential Therapeutic Target ◽  
Elementary Mode Analysis

Inhibition of C298S mutant of human aldose reductase for antidiabetic applications: Evidence from in silico elementary mode analysis of biological network model

2018 ◽  
Vol 119 (8) ◽  
pp. 6961-6973 ◽  
Author(s):  
Saif Khan ◽  
Tulika Bhardwaj ◽  
Pallavi Somvanshi ◽  
Raju K. Mandal ◽  
Sajad A. Dar ◽  
...  
Keyword(s):  
Network Model ◽  
Aldose Reductase ◽  
In Silico ◽  
Biological Network ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis

Phospholipase A2: A Potential Therapeutic Target in Inflammation and Cancer (In silico, In vitro, In vivo and Clinical Approach)

2015 ◽  
Vol 07 (08) ◽  
Author(s):  
Nagendra sastry Yarla ◽  
Koduri Satyakumar ◽  
Duppalapudi Srinivasu ◽  
Kaladhar DSVGK
Keyword(s):  
Phospholipase A2 ◽  
Therapeutic Target ◽  
In Silico ◽  
Clinical Approach ◽  
Potential Therapeutic Target

Identification of active pathways of Chlorella protothecoides by elementary mode analysis integrated with fluxomic data

2020 ◽  
Vol 45 ◽  
pp. 101767
Author(s):  
Lujing Ren ◽  
Xiaoman Sun ◽  
Lihui Zhang ◽  
Quanyu Zhao ◽  
He Huang
Keyword(s):  
Chlorella Protothecoides ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis

Quantification of metabolism in Saccharomyces cerevisiae under hyperosmotic conditions using elementary mode analysis

2012 ◽  
Vol 39 (6) ◽  
pp. 927-941 ◽  
Author(s):  
Jignesh H. Parmar ◽  
Sharad Bhartiya ◽  
K. V. Venkatesh
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis

scholarly journals Designing optimal cell factories: integer programming couples elementary mode analysis with regulation

2012 ◽  
Vol 6 (1) ◽  
pp. 103 ◽  
Author(s):  
Christian Jungreuthmayer ◽  
Jürgen Zanghellini
Keyword(s):  
Integer Programming ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis ◽  
Cell Factories

scholarly journals Integration of enzyme activities into metabolic flux distributions by elementary mode analysis

2007 ◽  
Vol 1 (1) ◽  
Author(s):  
Hiroyuki Kurata ◽  
Quanyu Zhao ◽  
Ryuichi Okuda ◽  
Kazuyuki Shimizu
Keyword(s):  
Enzyme Activities ◽  
Metabolic Flux ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis

scholarly journals IN-SILICO ANALYSIS OF TERPENOIDS IN SACCHAROMYCES CEREVISIAE

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Sudheer Menon
Keyword(s):  
Saccharomyces Cerevisiae ◽  
In Silico ◽  
Carbon Sources ◽  
In Silico Analysis ◽  
Mode Analysis ◽  
The Novel ◽  
Knock Out ◽  
Elementary Mode Analysis ◽  
Engineering Strategy ◽  
Host Metabolism

Heterologous production of terpenoids from plants which are of medicinal and industrial interests is getting much attention. For this purpose saccharomyces cerevisiae is the most commonly used host but the yield of terpenoids is much lower. The main aim of this review is to study the terpenoid pathways of saccharomyces cerevisiae, effect of respective host metabolism as well as to study the effect of different carbon sources in silico by means of elementary mode analysis. The production and yield of IPP was main focus point in order to find out the novel metabolic engineering strategy for increasing production of terpenoids. With glucose acting as a substrate, MVA pathway has low potential to produce terpenoids as compared to DXP pathway if we consider formation of precursor. Moreover the carbon source also has impact on yield with nonfermentable source providing more biomass. At last several knock out methodologies were being employed which identified minimal cuts sets for enhanced growth of terpenoids.

Elementary mode analysis and metabolic flux analysis of L-glutamate biosynthesis byCorynebacterium glutamicum

2009 ◽  
Vol 59 (2) ◽  
pp. 317-322 ◽  
Author(s):  
Ning Chen ◽  
Jun Du ◽  
Hui Liu ◽  
Qingyang Xu
Keyword(s):  
Metabolic Flux Analysis ◽  
Metabolic Flux ◽  
Mode Analysis ◽  
Flux Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis ◽  
Glutamate Biosynthesis
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