Inhibition of C298S mutant of human aldose reductase for antidiabetic applications: Evidence from in silico elementary mode analysis of biological network model

2018 ◽  
Vol 119 (8) ◽  
pp. 6961-6973 ◽  
Author(s):  
Saif Khan ◽  
Tulika Bhardwaj ◽  
Pallavi Somvanshi ◽  
Raju K. Mandal ◽  
Sajad A. Dar ◽  
...  
Keyword(s):  
Network Model ◽  
Aldose Reductase ◽  
In Silico ◽  
Biological Network ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis

Identification of active pathways of Chlorella protothecoides by elementary mode analysis integrated with fluxomic data

2020 ◽  
Vol 45 ◽  
pp. 101767
Author(s):  
Lujing Ren ◽  
Xiaoman Sun ◽  
Lihui Zhang ◽  
Quanyu Zhao ◽  
He Huang
Keyword(s):  
Chlorella Protothecoides ◽  
Mode Analysis ◽  
Elementary Mode ◽  
Elementary Mode Analysis

scholarly journals IN-SILICO ANALYSIS OF TERPENOIDS IN SACCHAROMYCES CEREVISIAE

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Sudheer Menon
Keyword(s):  
Saccharomyces Cerevisiae ◽  
In Silico ◽  
Carbon Sources ◽  
In Silico Analysis ◽  
Mode Analysis ◽  
The Novel ◽  
Knock Out ◽  
Elementary Mode Analysis ◽  
Engineering Strategy ◽  
Host Metabolism

Heterologous production of terpenoids from plants which are of medicinal and industrial interests is getting much attention. For this purpose saccharomyces cerevisiae is the most commonly used host but the yield of terpenoids is much lower. The main aim of this review is to study the terpenoid pathways of saccharomyces cerevisiae, effect of respective host metabolism as well as to study the effect of different carbon sources in silico by means of elementary mode analysis. The production and yield of IPP was main focus point in order to find out the novel metabolic engineering strategy for increasing production of terpenoids. With glucose acting as a substrate, MVA pathway has low potential to produce terpenoids as compared to DXP pathway if we consider formation of precursor. Moreover the carbon source also has impact on yield with nonfermentable source providing more biomass. At last several knock out methodologies were being employed which identified minimal cuts sets for enhanced growth of terpenoids.

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