MUC‐1 aptamer targeted superparamagnetic iron oxide nanoparticles for magnetic resonance imaging of pancreatic cancer in vivo and in vitro experiment

2019 ◽  
Vol 120 (11) ◽  
pp. 18650-18658 ◽  
Author(s):  
Qi Zou ◽  
Chong‐Jie Zhang ◽  
Yu‐Zhong Yan ◽  
Zhi‐Jun Min ◽  
Chun‐Sheng Li
Keyword(s):  
Magnetic Resonance Imaging ◽  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Vitro Experiment ◽  
In Vitro Experiment

Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: defining the structure and probing in vivo applications

Nanoscale ◽  
2016 ◽  
Vol 8 (19) ◽  
pp. 10078-10086 ◽  
Author(s):  
Alessandra Luchini ◽  
Carlo Irace ◽  
Rita Santamaria ◽  
Daniela Montesarchio ◽  
Richard K. Heenan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are performing contrast agents for Magnetic Resonance Imaging (MRI).

scholarly journals High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles

2020 ◽  
Vol 6 (29) ◽  
pp. eabb0998 ◽  
Author(s):  
David E. J. Waddington ◽  
Thomas Boele ◽  
Richard Maschmeyer ◽  
Zdenka Kuncic ◽  
Matthew S. Rosen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
High Contrast ◽  
Resonance Imaging ◽  
Low Field

Magnetic resonance imaging (MRI) scanners operating at ultra-low magnetic fields (ULF; <10 mT) are uniquely positioned to reduce the cost and expand the clinical accessibility of MRI. A fundamental challenge for ULF MRI is obtaining high-contrast images without compromising acquisition sensitivity to the point that scan times become clinically unacceptable. Here, we demonstrate that the high magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) at ULF makes possible relaxivity- and susceptibility-based effects unachievable with conventional contrast agents (CAs). We leverage these effects to acquire high-contrast images of SPIONs in a rat model with ULF MRI using short scan times. This work overcomes a key limitation of ULF MRI by enabling in vivo imaging of biocompatible CAs. These results open a new clinical translation pathway for ULF MRI and have broader implications for disease detection with low-field portable MRI scanners.

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