scholarly journals CTR9‐mediated JAK2/STAT3 pathway promotes the proliferation, migration, and invasion of human glioma cells

2021 ◽  
Author(s):  
Yang Xu ◽  
Jiaguo Chen ◽  
Gao He ◽  
Yuhai Zhang
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Stat3 Pathway

TSG101 Promotes the Proliferation, Migration, and Invasion of Human Glioma Cells by Regulating the AKT/GSK3β/β-Catenin and RhoC/Cofilin Pathways

2021 ◽  
Author(s):  
Yufu Zhu ◽  
Yang Xu ◽  
Tianze Chen ◽  
Yujian Zhang ◽  
Qiang Ma ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells

Knockdown of long non-coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR-34a

2017 ◽  
Vol 119 (3) ◽  
pp. 2708-2718 ◽  
Author(s):  
Xuechao Dong ◽  
Zheng Jin ◽  
Yong Chen ◽  
Haiyang Xu ◽  
Chengyuan Ma ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines

1995 ◽  
Vol 82 (6) ◽  
pp. 1035-1043 ◽  
Author(s):  
Jörg-Christian Tonn ◽  
Hans Kristian Haugland ◽  
Jaakko Saraste ◽  
Klaus Roosen ◽  
Ole Didrik Laerum
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Content Type ◽  
Glioma Cell Lines ◽  
Dose Dependent ◽  
Fine Print

✓ The aim of this study was to investigate the antimigratory and antiinvasive potential of vincristine sulfate (VCR) on human glioma cells and to analyze whether phenytoin (5,5-diphenylhydantoin; DPH) might act synergistically with VCR. Vincristine affects the cytoplasmic microtubules; DPH has been reported to enhance VCR cytotoxicity in murine cells. In two human glioma cell lines, GaMG and D-37MG, we found VCR to reduce monolayer growth and colony formation in a dose-dependent fashion at concentrations of 10 ng/ml and above. Phenytoin increased the cytotoxic and cystostatic effects of VCR in monolayer cells but not in spheroids. Multicellular spheroids were used to investigate directional migration. A coculture system of GaMG and D-37MG spheroids with fetal rat brain aggregates was used to analyze and quantify tumor cell invasion. A dose-dependent inhibition of migration and invasion by VCR was observed in both cell lines without further enhancement by DPH. Immunofluorescence microscopy with antibodies against α-tubulin revealed dose-dependent morphological alterations in the microtubules when the cells were exposed to VCR but not after incubation with DPH. Based on the combination of standardized in vitro model systems currently in use and the present data, the authors strongly suggest that VCR inhibits migration and invasion of human glioma cells. This is not altered by DPH, which inhibits cell proliferation in combination with VCR.

IL-1β microenvironment promotes proliferation, migration, and invasion of human glioma cells

2014 ◽  
Vol 38 (12) ◽  
pp. 1415-1422 ◽  
Author(s):  
K. Fathima Hurmath ◽  
Palaniswamy Ramaswamy ◽  
Dalavaikodihalli Nanjaiah Nandakumar
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals The Phosphorylation of EphB2 Receptor Regulates Migration and Invasion of Human Glioma Cells

2004 ◽  
Vol 64 (9) ◽  
pp. 3179-3185 ◽  
Author(s):  
Mitsutoshi Nakada ◽  
Jared A. Niska ◽  
Hisashi Miyamori ◽  
Wendy S. McDonough ◽  
Jie Wu ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals Forkhead box K2 inhibits the proliferation, migration, and invasion of human glioma cells and predicts a favorable prognosis

2018 ◽  
Vol Volume 11 ◽  
pp. 1067-1075 ◽  
Author(s):  
Bo Wang ◽  
XueBin Zhang ◽  
Wei Wang ◽  
ZhiZhong Zhu ◽  
Fan Tang ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Favorable Prognosis ◽  
Forkhead Box

FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-cadherin/β-catenin Complex Formation

2014 ◽  
Vol 55 (1) ◽  
pp. 32-41 ◽  
Author(s):  
Qiong Shi ◽  
Xu Song ◽  
Jun Wang ◽  
Jia Gu ◽  
Weijian Zhang ◽  
...  
Keyword(s):  
Complex Formation ◽  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells

miR-4530 inhibits the malignant biological behaviors of human glioma cells by directly targeting RTEL1

2020 ◽  
Vol 52 (12) ◽  
pp. 1394-1403
Author(s):  
Tuo Wang ◽  
Yan Zhang ◽  
Bo Cui ◽  
Maode Wang ◽  
Ya Li ◽  
...  
Keyword(s):  
Cell Lines ◽  
Nude Mice ◽  
Colony Formation ◽  
Glioma Cells ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
High Morbidity ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Over Expression

Abstract Human glioma is the most common primary brain tumor and is associated with high morbidity and mortality. Aberrant expressions of microRNAs (miRNAs) are involved in glioma progression. In the present study, we aimed to elucidate the roles of miR-4530 in the pathogenesis of gliomas. miR-4530 expression was examined in human glioma clinical tissues and cell lines including U251 and T98G. The target gene of miR-4530, RTEL1, was predicted with online tools and validated by luciferase reporter assay. Lentivirus infection, transfection of plasmids, and miRNA mimics were used to manipulate gene expression. Cell proliferation was determined using the CCK-8 method, and migration and invasion assays were determined with transwell experiments. Colony formation was measured by crystal violet staining, while apoptosis was determined by Annexin V/PI staining. The anti-tumor effects of miR-4530 were evaluated in nude mice xenografted using U251 cells. Our results showed that miR-4530 was significantly down-regulated in human glioma tissues and cell lines. miR-4530 over-expression inhibited the malignant behaviors of U251 and T98G cells, including reduced proliferation, diminished colony formation, migration and invasion, and increased apoptosis. Further mechanistic investigations revealed that RTEL1 is a direct functional target of miR-4530 in gliomas, and its over-expression remarkably reverses the effects of miR-4530 mimics on inhibiting these malignant behaviors. In addition, miR-4530 over-expression inhibited the growth of xenografted U251 glioma in nude mice. Therefore, miR-4530 acts as a tumor-suppressor gene and inhibits the malignant biological behaviors of human glioma cells, which is associated with directly targeting RTEL1. The miR-4530/RTEL1 axis is a potential therapeutic target for gliomas.

scholarly journals Suppression of CD44 expression decreases migration and invasion of human glioma cells

1996 ◽  
Vol 66 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Hideho Okada ◽  
Jun Yoshida ◽  
Masahiro Sokabe ◽  
Takashi Wakabayashi ◽  
Masatoshi Hagiwara
Keyword(s):  
Glioma Cells ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Cd44 Expression
Sign in / Sign up

Export Citation Format

Share Document