Caspase-3 inhibits the growth of breast cancer cells independent of protease activity

2004 ◽  
Vol 202 (2) ◽  
pp. 478-482 ◽  
Author(s):  
Beatrice Faraglia ◽  
Alessia Bonsignore ◽  
Franco Scaldaferri ◽  
Alma Boninsegna ◽  
Achille Cittadini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Protease Activity ◽  
Breast Cancer Cells ◽  
Caspase 3

scholarly journals Caspase‐3‐mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway

2021 ◽  
Author(s):  
Ziwen Zhang ◽  
Han Zhang ◽  
Dongbo Li ◽  
Xiaoping Zhou ◽  
Qi Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Signalling Pathway

Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model

2017 ◽  
Vol 8 (3) ◽  
pp. 1067-1079 ◽  
Author(s):  
Shih-Hsin Tu ◽  
Yi-Shiou Chiou ◽  
Nagabhushanam Kalyanam ◽  
Chi-Tang Ho ◽  
Li-Ching Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Breast Tumor ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Tumor Model ◽  
Breast Tumor Model

Garcinol sensitizes breast cancer cells to Taxolviasynergistically inducing antimitotic effects and effectively repressing the activation of caspase-3/iPLA2and Taxol-promoted NF-κB/Twist1 signaling pathways.

scholarly journals Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway

2019 ◽  
Vol 21 (1) ◽  
pp. 131 ◽  
Author(s):  
Jinxia Qiu ◽  
Tao Zhang ◽  
Xinying Zhu ◽  
Chao Yang ◽  
Yaxing Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Therapeutic Potential ◽  
B Cell Lymphoma ◽  
Flavonoid Glycosides

Hyperoside (quercetin 3-o-β-d-galactopyranoside) is one of the flavonoid glycosides with anti-inflammatory, antidepressant, and anti-cancer effects. But it remains unknown whether it had effects on breast cancer. Here, different concentrations of hyperoside were used to explore its therapeutic potential in both breast cancer cells and subcutaneous homotransplant mouse model. CCK-8 and wound healing assays showed that the viability and migration capability of Michigan Cancer Foundation-7 (MCF-7) and 4T1 cells were inhibited by hyperoside, while the apoptosis of cells were increased. Real-time quantitative PCR (qRT-PCR) and western blot analysis were used to detect mRNA and the protein level, respectively, which showed decreased levels of B cell lymphoma-2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP), and increased levels of Bax and cleaved caspase-3. After exploration of the potential mechanism, we found that reactive oxygen species (ROS) production was reduced by the administration of hyperoside, which subsequently inhibited the activation of NF-κB signaling pathway. Tumor volume was significantly decreased in subcutaneous homotransplant mouse model in hyperoside-treated group, which was consistent with our study in vitro. These results indicated that hyperoside acted as an anticancer drug through ROS-related apoptosis and its mechanism included activation of the Bax–caspase-3 axis and the inhibition of the NF-κB signaling pathway.

scholarly journals The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Bernhard Kötter ◽  
Benjamin Frey ◽  
Markus Winderl ◽  
Yvonne Rubner ◽  
Heike Scheithauer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Hypofractionated Irradiation

Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells

2021 ◽  
Vol 340 ◽  
pp. 109434
Author(s):  
Yaqiong Li ◽  
Wei Wang ◽  
Aixia Li ◽  
Wei Huang ◽  
Shiman Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Caspase 3

Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo

2017 ◽  
Vol 89 ◽  
pp. 827-837 ◽  
Author(s):  
Na-na Han ◽  
Qi Zhou ◽  
Qian Huang ◽  
Kai-jiang Liu
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Carnosic Acid

Resveratrol-induced Apoptosis in Human Breast Cancer Cells Is Mediated Primarily through the Caspase-3-dependent Pathway

2008 ◽  
Vol 39 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Moussa Alkhalaf ◽  
Abdulla El-Mowafy ◽  
Waleed Renno ◽  
Ousama Rachid ◽  
Ahmed Ali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis ◽  
Dependent Pathway

scholarly journals Proapoptotic and Antiproliferative Effects ofThymus caramanicuson Human Breast Cancer Cell Line (MCF-7) and Its Interaction with Anticancer Drug Vincristine

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Saeed Esmaeili-Mahani ◽  
Farzaneh Falahi ◽  
Mohammad Mehdi Yaghoobi
Keyword(s):  
Breast Cancer ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Thymus caramanicus Jalasis one of the species of thymus that grows in the wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diabetes, arthritis, and cancerous situation. Therefore, the present study was designed to investigate the selective cytotoxic and antiproliferative properties ofThymus caramanicusextract (TCE). MCF-7 human breast cancer cells were used in this study. Cytotoxicity of the extract was determined using MTT and neutral red assays. Biochemical markers of apoptosis (caspase 3, Bax, and Bcl-2) and cell proliferation (cyclin D1) were evaluated by immunoblotting. Vincristine was used as anticancer control drug in extract combination therapy. The data showed that incubation of cells with TCE (200 and 250 μg/mL) significantly increased cell damage, activated caspase 3 and Bax/Bcl2 ratio. In addition, cyclin D1 was significantly decreased in TCE-treated cells. Furthermore, concomitant treatment of cells with extract and anticancer drug produced a significant cytotoxic effect as compared to extract or drugs alone. In conclusion, thymus extract has a potential proapoptotic/antiproliferative property against human breast cancer cells and its combination with chemotherapeutic agent vincristine may induce cell death effectively and be a potent modality to treat this type of cancer.

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