Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism

2010 ◽  
Vol 226 (3) ◽  
pp. 579-587 ◽  
Author(s):  
Nissar Ahmad Wani ◽  
Jyotdeep Kaur
Keyword(s):  
Lipid Rafts ◽  
Chronic Alcoholism ◽  
Membrane Lipid ◽  
Folate Transporters

scholarly journals Decreased activity of folate transporters in lipid rafts resulted in reduced hepatic folate uptake in chronic alcoholism in rats

2012 ◽  
Vol 8 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Nissar Ahmad Wani ◽  
Ritambhara Nada ◽  
Krishan Lal Khanduja ◽  
Jyotdeep Kaur
Keyword(s):  
Lipid Rafts ◽  
Chronic Alcoholism ◽  
Folate Transporters

Su2005 Downregulation of Folate Transporters in Membrane Lipid Rafts Contributes to Decreased Hepatic Folate Uptake in Ethanol Fed Rats

2012 ◽  
Vol 142 (5) ◽  
pp. S-558
Author(s):  
Nissar Ahmad A. Wani ◽  
Ritambhra Nada ◽  
Krishan Lal Khanduja ◽  
Jyotdeep Kaur
Keyword(s):  
Lipid Rafts ◽  
Membrane Lipid ◽  
Folate Transporters

scholarly journals Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hamza Amine ◽  
Yacir Benomar ◽  
Mohammed Taouis
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Palmitic Acid ◽  
Lipid Rafts ◽  
Acid Treatment ◽  
Protective Action ◽  
Saturated Fatty Acids ◽  
Membrane Lipid ◽  
Human Neuroblastoma ◽  
Peripheral Tissues

AbstractSaturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid. Palmitic acid effects have been in part attributed to its potential action through Toll-like receptor 4. Beside, resistin, an adipokine, also promotes inflammation and insulin resistance via TLR4. In the brain, palmitic acid and resistin trigger neuroinflammation and insulin resistance, but their link at the neuronal level is unknown. Using human SH-SY5Yneuroblastoma cell line we show that palmitic acid treatment impaired insulin-dependent Akt and Erk phosphorylation whereas DHA preserved insulin action. Palmitic acid up-regulated TLR4 as well as pro-inflammatory cytokines IL6 and TNFα contrasting with DHA effect. Similarly to palmitic acid, resistin treatment induced the up-regulation of IL6 and TNFα as well as NFκB activation. Importantly, palmitic acid potentiated the resistin-dependent NFkB activation whereas DHA abolished it. The recruitment of TLR4 to membrane lipid rafts was increased by palmitic acid treatment; this is concomitant with the augmentation of resistin-induced TLR4/MYD88/TIRAP complex formation mandatory for TLR4 signaling. In conclusion, palmitic acid increased TLR4 expression promoting resistin signaling through TLR4 up-regulation and its recruitment to membrane lipid rafts.

1P-0227 Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages

2003 ◽  
Vol 4 (2) ◽  
pp. 69 ◽  
Author(s):  
W. Jessup ◽  
K. Gaus ◽  
L. Kritharides ◽  
A. Boettcher ◽  
W. Drobnik ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Lipid Rafts ◽  
Membrane Lipid ◽  
Apolipoprotein A ◽  
Plasma Membrane Lipid

Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes

2010 ◽  
Vol 24 (4) ◽  
pp. 639-642 ◽  
Author(s):  
Hironori Tsuchiya ◽  
Takahiro Ueno ◽  
Maki Mizogami ◽  
Ko Takakura
Keyword(s):  
Lipid Rafts ◽  
Local Anesthetics ◽  
Membrane Lipid

Chapter 13 The Pivotal Role of Cholesterol and Membrane Lipid Rafts in the Ca

2016 ◽  
pp. 333-342
Author(s):  
Ying Zhang ◽  
Hiroko Kishi ◽  
Katsuko Kajiya ◽  
Tomoka Morita ◽  
Sei Kobayashi
Keyword(s):  
Lipid Rafts ◽  
Membrane Lipid ◽  
Pivotal Role

scholarly journals Interaction of drugs with lipid raft membrane domains as a possible target

2020 ◽  
Vol 14 (1) ◽  
pp. 34-47
Author(s):  
Hironori Tsuchiya ◽  
Maki Mizogami
Keyword(s):  
Membrane Fluidity ◽  
Lipid Rafts ◽  
Lipid Raft ◽  
Plasma Membranes ◽  
Cellular Membrane ◽  
Membrane Lipid ◽  
Membrane Domains ◽  
Functional Protein ◽  
Lipid Complex ◽  
Physicochemical Changes

Introduction: Plasma membranes are not the homogeneous bilayers of uniformly distributed lipids but the lipid complex with laterally separated lipid raft membrane domains, which provide receptor, ion channel and enzyme proteins with a platform. The aim of this article is to review the mechanistic interaction of drugs with membrane lipid rafts and address the question whether drugs induce physicochemical changes in raft-constituting and raft-surrounding membranes. Methods: Literature searches of PubMed/MEDLINE and Google Scholar databases from 2000 to 2020 were conducted to include articles published in English in internationally recognized journals. Collected articles were independently reviewed by title, abstract and text for relevance. Results: The literature search indicated that pharmacologically diverse drugs interact with raft model membranes and cellular membrane lipid rafts. They could physicochemically modify functional protein-localizing membrane lipid rafts and the membranes surrounding such domains, affecting the raft organizational integrity with the resultant exhibition of pharmacological activity. Raft-acting drugs were characterized as ones to decrease membrane fluidity, induce liquid-ordered phase or order plasma membranes, leading to lipid raft formation; and ones to increase membrane fluidity, induce liquid-disordered phase or reduce phase transition temperature, leading to lipid raft disruption. Conclusion: Targeting lipid raft membrane domains would open a new way for drug design and development. Since angiotensin-converting enzyme 2 receptors which are a cell-specific target of and responsible for the cellular entry of novel coronavirus are localized in lipid rafts, agents that specifically disrupt the relevant rafts may be a drug against coronavirus disease 2019.

Fluorescent Labeling of Membrane Lipid Rafts

2011 ◽  
Vol 2011 (5) ◽  
pp. pdb.prot5625-pdb.prot5625 ◽  
Author(s):  
B. Chazotte
Keyword(s):  
Lipid Rafts ◽  
Membrane Lipid ◽  
Fluorescent Labeling
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