p38α MAPK mediates 17β-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells

2012 ◽  
Vol 227 (11) ◽  
pp. 3648-3660 ◽  
Author(s):  
Hsi-Hsien Hsu ◽  
Chung-Jung Liu ◽  
Chia-Yao Shen ◽  
Yi-Jyun Chen ◽  
Li-Mien Chen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P38α Mapk ◽  
17Β Estradiol

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

2015 ◽  
Vol 459 (2) ◽  
pp. 327-332 ◽  
Author(s):  
Peng Yang ◽  
Zongwei Li ◽  
Yingying Wang ◽  
Lichao Zhang ◽  
Haili Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Colon Cancer Cells ◽  
Pyruvate Kinase M2

scholarly journals Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transition

Oncogene ◽  
2015 ◽  
Vol 35 (24) ◽  
pp. 3151-3162 ◽  
Author(s):  
Q Zhang ◽  
T Wei ◽  
K Shim ◽  
K Wright ◽  
K Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Mesenchymal Transition ◽  
E Cadherin

Abstract Sprouty (SPRY) appears to act as a tumor suppressor in cancer, whereas we demonstrated that SPRY2 functions as a putative oncogene in colorectal cancer (CRC) (Oncogene, 2010, 29: 5241–5253). We investigated the mechanisms by which SPRY regulates epithelial–mesenchymal transition (EMT) in CRC. SPRY1 and SPRY2 mRNA transcripts were significantly upregulated in human CRC. Suppression of SPRY2 repressed AKT2 and EMT-inducing transcription factors and significantly increased E-cadherin expression. Concurrent downregulation of SPRY1 and SPRY2 also increased E-cadherin and suppressed mesenchymal markers in colon cancer cells. An inverse expression pattern between AKT2 and E-cadherin was established in a human CRC tissue microarray. SPRY2 negatively regulated miR-194-5p that interacts with AKT2 3′ untranslated region. Mir-194 mimics increased E-cadherin expression and suppressed cancer cell migration and invasion. By confocal microscopy, we demonstrated redistribution of E-cadherin to plasma membrane in colon cancer cells transfected with miR-194. Spry1 −/− and Spry2 −/− double mutant mouse embryonic fibroblasts exhibited decreased cell migration while acquiring several epithelial markers. In CRC, SPRY drive EMT and may serve as a biomarker of poor prognosis.

scholarly journals Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells

2016 ◽  
Vol 50 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Sara Häggblad Sahlberg ◽  
Anja C. Mortensen ◽  
Jakob Haglöf ◽  
Mikael K.R. Engskog ◽  
Torbjörn Arvidsson ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Molecular Pathways ◽  
Colon Cancer Cells

Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation

2010 ◽  
Vol 391 (1) ◽  
pp. 921-925 ◽  
Author(s):  
Youngsil Choi ◽  
Hyunjung Kim ◽  
Heesung Chung ◽  
Ji-Sun Hwang ◽  
Jin-A Shin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Colon Cancer Cells

5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells

2016 ◽  
Vol 40 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Kyuhwa Seo ◽  
Sung Hwan Ki ◽  
Eun Young Park ◽  
Sang Mi Shin
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Colon Cancer Cells
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