Claudin7b is required for the formation and function of inner ear in zebrafish

2017 ◽  
Vol 233 (4) ◽  
pp. 3195-3206 ◽  
Author(s):  
Xiaohui Li ◽  
Guili Song ◽  
Yasong Zhao ◽  
Feng Zhao ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Inner Ear ◽  
And Function

Recovery of structure and function of inner ear afferent synapses following kainic acid excitotoxicity

1997 ◽  
Vol 105 (1-2) ◽  
pp. 65-76 ◽  
Author(s):  
Xiang-Yang Zheng ◽  
Donald Henderson ◽  
Bo-Hua Hu ◽  
Sandra L. McFadden
Keyword(s):  
Inner Ear ◽  
Kainic Acid ◽  
Structure And Function ◽  
And Function

scholarly journals Expression and function of pannexins in the inner ear and hearing

2016 ◽  
Vol 17 (S1) ◽  
Author(s):  
Hong-Bo Zhao
Keyword(s):  
Inner Ear ◽  
And Function

scholarly journals Broken force dispersal network in tip-links by the mutations at the Ca2+-binding residues induces hearing-loss

2019 ◽  
Vol 476 (16) ◽  
pp. 2411-2425 ◽  
Author(s):  
Jagadish P. Hazra ◽  
Amin Sagar ◽  
Nisha Arora ◽  
Debadutta Deb ◽  
Simerpreet Kaur ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Single Molecule ◽  
Force Sensor ◽  
Force Sensors ◽  
Single Molecule Level ◽  
Conformational Variability ◽  
Atomic Force ◽  
Wide Range ◽  
And Function

Abstract Tip-link as force-sensor in hearing conveys the mechanical force originating from sound to ion-channels while maintaining the integrity of the entire sensory assembly in the inner ear. This delicate balance between structure and function of tip-links is regulated by Ca2+-ions present in endolymph. Mutations at the Ca2+-binding sites of tip-links often lead to congenital deafness, sometimes syndromic defects impairing vision along with hearing. Although such mutations are already identified, it is still not clear how the mutants alter the structure-function properties of the force-sensors associated with diseases. With an aim to decipher the differences in force-conveying properties of the force-sensors in molecular details, we identified the conformational variability of mutant and wild-type tip-links at the single-molecule level using FRET at the endolymphatic Ca2+ concentrations and subsequently measured the force-responsive behavior using single-molecule force spectroscopy with an Atomic Force Microscope (AFM). AFM allowed us to mimic the high and wide range of force ramps (103–106 pN s−1) as experienced in the inner ear. We performed in silico network analysis to learn that alterations in the conformations of the mutants interrupt the natural force-propagation paths through the sensors and make the mutant tip-links vulnerable to input forces from sound stimuli. We also demonstrated that a Ca2+ rich environment can restore the force-response of the mutant tip-links which may eventually facilitate the designing of better therapeutic strategies to the hearing loss.

scholarly journals New insights into regulation and function of planar polarity in the inner ear

2019 ◽  
Vol 709 ◽  
pp. 134373 ◽  
Author(s):  
Basile Tarchini ◽  
Xiaowei Lu
Keyword(s):  
Inner Ear ◽  
Planar Polarity ◽  
And Function

scholarly journals MicroRNAs are essential for development and function of inner ear hair cells in vertebrates

2009 ◽  
Vol 106 (19) ◽  
pp. 7915-7920 ◽  
Author(s):  
L. M. Friedman ◽  
A. A. Dror ◽  
E. Mor ◽  
T. Tenne ◽  
G. Toren ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
And Function

scholarly journals Influence of Middle Ear Immune Response on the Immunological State and Function of the Inner Ear

1992 ◽  
Vol 102 (2) ◽  
pp. 177???181 ◽  
Author(s):  
B. Gloddek ◽  
Kerstin Lamm ◽  
K. Haslov
Keyword(s):  
Immune Response ◽  
Inner Ear ◽  
Middle Ear ◽  
And Function

A Novel Microperfusion System for the Long-Term Local Supply of Drugs to the Inner Ear: Implantation and Function in the Rat Model

2001 ◽  
Vol 6 (5) ◽  
pp. 250-258 ◽  
Author(s):  
Mark Praetorius ◽  
Annette Limberger ◽  
Marcus Müller ◽  
Rolf Lehner ◽  
Bernhard Schick ◽  
...  
Keyword(s):  
Inner Ear ◽  
Rat Model ◽  
Local Supply ◽  
And Function

scholarly journals Id Gene Regulation and Function in the Prosensory Domains of the Chicken Inner Ear: A Link between Bmp Signaling and Atoh1

2010 ◽  
Vol 30 (34) ◽  
pp. 11426-11434 ◽  
Author(s):  
A. Kamaid ◽  
J. Neves ◽  
F. Giraldez
Keyword(s):  
Gene Regulation ◽  
Inner Ear ◽  
Bmp Signaling ◽  
And Function

scholarly journals Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D andDFNB31

2015 ◽  
Vol 24 (21) ◽  
pp. 6213-6228 ◽  
Author(s):  
Pranav Dinesh Mathur ◽  
Junhuang Zou ◽  
Tihua Zheng ◽  
Ali Almishaal ◽  
Yong Wang ◽  
...  
Keyword(s):  
Inner Ear ◽  
And Function ◽  
Insight Into
Sign in / Sign up

Export Citation Format

Share Document