scholarly journals Pharmacokinetics of Risankizumab in Asian Healthy Subjects and Patients With Moderate to Severe Plaque Psoriasis, Generalized Pustular Psoriasis, and Erythrodermic Psoriasis

2019 ◽  
Vol 59 (12) ◽  
pp. 1656-1668 ◽  
Author(s):  
Amit Khatri ◽  
Doerthe Eckert ◽  
Rajneet Oberoi ◽  
Ahmed Suleiman ◽  
Yinuo Pang ◽  
...  
Keyword(s):  
Plaque Psoriasis ◽  
Healthy Subjects ◽  
Pustular Psoriasis ◽  
Severe Plaque Psoriasis ◽  
Generalized Pustular Psoriasis ◽  
Erythrodermic Psoriasis

scholarly journals Clinico-epidemiological study of childhood psoriasis

2017 ◽  
Vol 10 (2) ◽  
pp. 119 ◽  
Author(s):  
Mohammed Saiful Islam Bhuiyan ◽  
A. S. M. Zakaria ◽  
Abida Sultana ◽  
A. K. M. Zayedul Haque ◽  
Sabbir Muhammad Shawkat
Keyword(s):  
Epidemiological Study ◽  
Plaque Psoriasis ◽  
Epidemiological Data ◽  
Common Type ◽  
Pustular Psoriasis ◽  
Joint Involvement ◽  
Psoriasis Plaque ◽  
Erythrodermic Psoriasis ◽  
The Mean ◽  
Nail Involvement

<p>The clinico-epidemiological data of 276 childhood psoriasis were studied. The mean age was 7.64 years (range 1 day to 15 years). There was no complain of any discomfort in 198 cases. Itching was present in 67 cases and burning in 11 cases. Plaque psoriasis was the most common type (68.8%) followed by guttate (18.8%). Erythrodermic and pustular psoriasis were found in 2.2% and 1.5% cases. Scalp was the most frequently affected site (75.36%) followed by extensors of extremities (41.3%), trunk (37.7%), palm and/or sole (13.0%) and diaper area (11.6%). Nail involvement was found only in 8%, joint was affected in 3.6% and only 2.2% children with psoriasis were erythrodermic. In Bangladeshi children with psoriasis, plaque is the most common type and scalp is the mostly affect site. Nail and joint involvement is less common. Pustular and erythrodermic psoriasis is rare.</p>

scholarly journals Localized pustular psoriasis in a child treated successfully with topical dapsone gel

2021 ◽  
Author(s):  
Vidya Kharkar ◽  
Surender Singh ◽  
Yallappa Ramachandrappa Kabbannavar
Keyword(s):  
Adverse Effects ◽  
Plaque Psoriasis ◽  
Paediatric Population ◽  
Common Type ◽  
Effective Therapy ◽  
Pustular Psoriasis ◽  
Age Group ◽  
Immune Mediated ◽  
Paediatric Age ◽  
Erythrodermic Psoriasis

<p class="abstract">Psoriasis is a chronic inflammatory, immune mediated dermatosis in children and adults. About one third of cases affected with psoriasis have their onset in first and second decade of life. Of paediatric population, about 0.5-2% is affected, infants are rarely affected. Overall plaque psoriasis is most common type followed by guttate and pustular psoriasis. Treating severe forms of psoriasis such as pustular psoriasis and erythrodermic psoriasis can pose difficulties, especially in paediatric population. Hence paediatric psoriasis needs to be managed effectively, however effective therapy also poses the risk of producing adverse effects, more so in paediatric age group. We report a case of localized pustular psoriasis, with an antineutrophil agent which is much safer and may target directly the pathophysiology of pustular psoriasis.</p>

scholarly journals Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Pilar Alvarez ◽  
Liselotte E. Jensen
Keyword(s):  
Mouse Model ◽  
Inflammatory Mediators ◽  
Plaque Psoriasis ◽  
Systemic Disease ◽  
Severe Disease ◽  
Skin Inflammation ◽  
Pustular Psoriasis ◽  
Dependent Manner ◽  
Missense Mutations ◽  
Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) is a severe form of psoriasis that can be caused by missense mutations in the interleukin-36 (IL-36) receptor antagonist. In addition to neutrophil rich skin inflammation, GPP patients typically also experience anorexia, fever, malaise, and pain. The imiquimod-induced skin inflammation mouse model has rapidly become a popular way to study plaque psoriasis, which typically does not involve symptoms of systemic disease. In this model, neutrophil recruitment to the skin is dependent upon the inflammatory mediators IL-1, via its receptor IL-1R1, and IL-36α. Unexpectedly, we observed that mice also exhibited signs of anorexia (weight loss and decreased food intake), general malaise (decreased activity and loss of interest in building nests), and pain (nose bulging and hunched posture). A scoring system allowing quantitative comparisons of test groups was developed. Female mice were found to develop more severe disease than male mice. Furthermore, mice deficient in both IL-1R1 and IL-36α are nearly disease-free, while mice lacking only one of these inflammatory mediators have less severe disease than wild type mice. Hence, the imiquimod-induced skin inflammation mouse model recapitulates not only plaque psoriasis, but also the more severe symptoms, that is, anorexia, malaise, and pain, seen in GPP.

Successful Secukinumab treatment of generalized pustular psoriasis and erythrodermic psoriasis

2017 ◽  
Vol 31 (9) ◽  
pp. e420-e421 ◽  
Author(s):  
C. Mugheddu ◽  
L. Atzori ◽  
A. Lappi ◽  
M. Pau ◽  
S. Murgia ◽  
...  
Keyword(s):  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis ◽  
Erythrodermic Psoriasis
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