Localized pustular psoriasis in a child treated successfully with topical dapsone gel

<p class="abstract">Psoriasis is a chronic inflammatory, immune mediated dermatosis in children and adults. About one third of cases affected with psoriasis have their onset in first and second decade of life. Of paediatric population, about 0.5-2% is affected, infants are rarely affected. Overall plaque psoriasis is most common type followed by guttate and pustular psoriasis. Treating severe forms of psoriasis such as pustular psoriasis and erythrodermic psoriasis can pose difficulties, especially in paediatric population. Hence paediatric psoriasis needs to be managed effectively, however effective therapy also poses the risk of producing adverse effects, more so in paediatric age group. We report a case of localized pustular psoriasis, with an antineutrophil agent which is much safer and may target directly the pathophysiology of pustular psoriasis.</p>

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Clinico-epidemiological study of childhood psoriasis

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v10i2.32710 ◽

2017 ◽

Vol 10 (2) ◽

pp. 119 ◽

Cited By ~ 1

Author(s):

Mohammed Saiful Islam Bhuiyan ◽

A. S. M. Zakaria ◽

Abida Sultana ◽

A. K. M. Zayedul Haque ◽

Sabbir Muhammad Shawkat

Keyword(s):

Epidemiological Study ◽

Plaque Psoriasis ◽

Epidemiological Data ◽

Common Type ◽

Pustular Psoriasis ◽

Joint Involvement ◽

Psoriasis Plaque ◽

Erythrodermic Psoriasis ◽

The Mean ◽

Nail Involvement

<p>The clinico-epidemiological data of 276 childhood psoriasis were studied. The mean age was 7.64 years (range 1 day to 15 years). There was no complain of any discomfort in 198 cases. Itching was present in 67 cases and burning in 11 cases. Plaque psoriasis was the most common type (68.8%) followed by guttate (18.8%). Erythrodermic and pustular psoriasis were found in 2.2% and 1.5% cases. Scalp was the most frequently affected site (75.36%) followed by extensors of extremities (41.3%), trunk (37.7%), palm and/or sole (13.0%) and diaper area (11.6%). Nail involvement was found only in 8%, joint was affected in 3.6% and only 2.2% children with psoriasis were erythrodermic. In Bangladeshi children with psoriasis, plaque is the most common type and scalp is the mostly affect site. Nail and joint involvement is less common. Pustular and erythrodermic psoriasis is rare.</p>

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Pattern of Corneal Diseases in Paediatric Age Group at a Tertiary Eye Care Center in Nepal

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v9i1.17531 ◽

2017 ◽

Vol 9 (1) ◽

pp. 37-42

Author(s):

A Shah ◽

M Chaudhary ◽

J K Shrestha

Keyword(s):

Care Center ◽

Paediatric Population ◽

Cross Sectional Study ◽

Common Type ◽

Age Group ◽

Sectional Study ◽

Eye Care ◽

Cross Sectional ◽

Corneal Infection ◽

Paediatric Age

Objective: It is to study the pattern of corneal diseases (including injuries) in paediatric population in a tertiary eye care center. Materials and methods: A descriptive, cross sectional study was carried out in a tertiary eye care center which included 176 cases. Results: Out of 176 cases studied, 6 cases (3.4%) presented with congenital causes, 4 cases (2.27%) were of dystrophy and ectasia, 63 cases (35.79%) had infective origin, 17 cases (9.65%) had inflammatory cause, 9 cases (5.11%) had systemic association and 77 cases (43.75%) had traumatic causes. Conclusion: Trauma was noted to be the most important cause for corneal diseases in paediatric population followed by infective conditions. Viral keratitis was found to be the most common type of corneal infection in the paediatric age group.

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Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J)

The Journal of Dermatology ◽

10.1111/1346-8138.13622 ◽

2016 ◽

Vol 44 (4) ◽

pp. 355-362 ◽

Cited By ~ 67

Author(s):

Hidehisa Saeki ◽

Hidemi Nakagawa ◽

Ko Nakajo ◽

Taeko Ishii ◽

Yoji Morisaki ◽

...

Keyword(s):

Plaque Psoriasis ◽

Japanese Patients ◽

Pustular Psoriasis ◽

Efficacy And Safety ◽

Open Label ◽

Phase 3 ◽

Severe Plaque Psoriasis ◽

Generalized Pustular Psoriasis ◽

Open Label Phase ◽

Erythrodermic Psoriasis

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Pharmacokinetics of Risankizumab in Asian Healthy Subjects and Patients With Moderate to Severe Plaque Psoriasis, Generalized Pustular Psoriasis, and Erythrodermic Psoriasis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1473 ◽

2019 ◽

Vol 59 (12) ◽

pp. 1656-1668 ◽

Cited By ~ 10

Author(s):

Amit Khatri ◽

Doerthe Eckert ◽

Rajneet Oberoi ◽

Ahmed Suleiman ◽

Yinuo Pang ◽

...

Keyword(s):

Plaque Psoriasis ◽

Healthy Subjects ◽

Pustular Psoriasis ◽

Severe Plaque Psoriasis ◽

Generalized Pustular Psoriasis ◽

Erythrodermic Psoriasis

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Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/jdv.12773 ◽

2014 ◽

Vol 29 (6) ◽

pp. 1148-1155 ◽

Cited By ~ 59

Author(s):

H. Saeki ◽

H. Nakagawa ◽

T. Ishii ◽

Y. Morisaki ◽

T. Aoki ◽

...

Keyword(s):

Plaque Psoriasis ◽

Japanese Patients ◽

Pustular Psoriasis ◽

Efficacy And Safety ◽

Open Label ◽

Severe Plaque Psoriasis ◽

Generalized Pustular Psoriasis ◽

Erythrodermic Psoriasis

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Bevacizumab in Retinopathy of Prematurity : Concerns and adverse effects

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v12i2.28993 ◽

2020 ◽

Vol 12 (2) ◽

pp. 298-307

Author(s):

Anuj Sharma ◽

Adheesh Shetty ◽

Y.C. Venu Gopal Reddy

Keyword(s):

Developing Countries ◽

Adverse Effects ◽

Retinopathy Of Prematurity ◽

Controlled Trial ◽

Case Series ◽

Intravitreal Bevacizumab ◽

Vital Role ◽

Age Group ◽

Paediatric Age ◽

Randomised Controlled

Retinopathy of prematurity (ROP) ranks as one of the leading causes of blindness in the paediatric age group, the incidence of which is increasing in developing countries as the economy strengthens and healthcare practices improve. As a vasoproliferative disorder affecting premature neonates VEGF is said to play a vital role in the pathogenesis of ROP. Evidence of the efficacy of anti-VEGF agents in treatment of ROP have been seen in literature since early 2007 with most published reports being either case studies or small case series. The only randomised controlled trial in this regard was the BEAT-ROP study which was published in 2011. However, even in that study the adverse effects of Bevacizumab were not analysed. This review aims to discuss the complications prior to the blanket administration of intravitreal bevacizumab in the management of ROP.

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Evaluation of Efficacy and Safety of Age-Based Intrathecal Dosing of 0.5% Hyperbaric Bupivacaine in the Paediatric Age Group

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/44618.14166 ◽

2020 ◽

Author(s):

Parthasarathy Srinivasan ◽

Balachandar Saravanan ◽

Indu Kulandayan ◽

Senthilkumar Thambidurai ◽

VN Mahalakshmi

Keyword(s):

Success Rate ◽

Surgical Procedures ◽

Spinal Anaesthesia ◽

Paediatric Population ◽

Age Group ◽

Hyperbaric Bupivacaine ◽

Sensory Blockade ◽

Paediatric Patients ◽

Paediatric Age ◽

The Mean

Introduction: Spinal anaesthesia in the paediatric population is a safe and reliable method of anaesthesia for infraumbilical surgical procedures. As there is greater variation in intrathecal dosing using a conventional weight-based schedule, a prospective cohort study was designed to administer an age-based intrathecal dosing schedule using 0.5% hyperbaric bupivacaine for infraumbilical surgeries in paediatric patients. Aim: To find the efficacy of age-based intrathecal dosing in terms of level of sensory blockade, success rate and adequacy of blockade for infraumbilical surgery in the paediatric age group. Materials and Methods: One hundred and thirty paediatric patients, aged between 2-12 years, posted for elective infraumbilical surgeries were given spinal anaesthesia at a dose of Age/5 (Partha formula) using 0.5% hyperbaric bupivacaine. Sedation during the procedure was provided using a combination of effective doses of pentazocine, midazolam, and atropine. The number of attempts, the success rate, the level of sensory blockade, the duration of anaesthesia and cardio-respiratory complications if any were noted. Results: The mean age of the children was 8±2.55 years. The mean dose of 0.5% hyperbaric bupivacaine used in this study was 8±2.55 milligrams. The desired sensory level of T10 was achieved in the first attempt in all the cases (100%) within 10 minutes of the subarachnoid block. The mean duration of anaesthesia was 73.42±18.6 minutes. In all the patients, the surgical procedures were completed within this anaesthetic time and none of the cases had any conversion to general anaesthesia. No complications were found in any of the patients. Conclusion: Administration of intrathecal dosing of 0.5% hyperbaric bupivacaine using Partha formula (Age/5) is a safe and successful method to provide subarachnoid blockade for infraumbilical surgeries in the Indian paediatric population.

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Incidence of Cerebral Hemorrhage in Traumatic Patients using Computed Tomography in Tabuk City, Saudi Arabia

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol05-i10/971 ◽

2020 ◽

Vol 5 (10) ◽

pp. 460-463

Author(s):

Amna Mohamed Ahmed ◽

Towmader Awad ◽

Hajer Yousif ◽

Reem Nahari ◽

Omnia Abdelrhman ◽

...

Keyword(s):

Computed Tomography ◽

Saudi Arabia ◽

Head Trauma ◽

Subdural Hematoma ◽

Cerebral Hemorrhage ◽

Imaging Modality ◽

Common Type ◽

Radiology Department ◽

Age Group ◽

Ct Finding

Computed Tomography (CT) is the most commonly used imaging modality in the evaluation of cerebral hemorrhage in the head trauma patients. Objective: To study the incidence of a cerebral hemorrhage in traumatic patients using computed tomography. Method: This retrospective study was conducted at King Khalid hospital in Tabuk city, Saudi Arabia, in the radiology department, in the period from September 2018 to April 2020. The study was done by collecting 471 CT reports of patients all of them were exposed to head trauma with deferent reasons. The data were analyzed by Statistical Package for the Social Sciences (SPSS) program (ver. 20) and presented in tables and graphs according to the checklist which includes: patient age, gender, type of trauma, CT finding, and type of hemorrhage. Results: The most age group suffered from head trauma was less than 20 years percentage (55%), The male patients more exposed to head trauma than female patients with percentage (84.5%), the road traffic accident (RTA) is the most common type of trauma by percentage (63.5%), according to the CT finding; the cerebral hemorrhage represented (15.5%) with the highest percentage in a subdural hematoma (31.2%), the fracture represented (2.8%) while the normal appearance represented (81.7%) as the highest percentage. Conclusion: Most of the traumatic brain injury in patients caused cerebral hemorrhage and the CT scan reports show that: the common type of cerebral hemorrhage is subdural hematoma and it is common in males which exposed to (RTA) in the age group (21 - 40) years old.

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