Suspected Adverse Drug Reactions From Corticosteroids: Analysis of Reported Notifications to the Portuguese Pharmacovigilance System

2020 ◽  
Vol 60 (10) ◽  
pp. 1367-1375
Author(s):  
Cristel Gonçalves ◽  
Cristina Monteiro ◽  
Jorge Luiz Santos
Keyword(s):  
Adverse Drug Reactions ◽  
Pharmacovigilance System ◽  
Drug Reactions ◽  
Suspected Adverse Drug Reactions

scholarly journals PATTERN OF ADVERSE DRUG REACTIONS AND ITS MANAGEMENT IN FEMALE CANCER PATIENTS IN A PRIVATE HOSPITAL IN TELANGANA, INDIA

2018 ◽  
Vol 6 (4) ◽  
pp. 45-53
Author(s):  
Kishore P ◽  
G Meghana ◽  
B. Pratap Reddy ◽  
K V Raghavaiah ◽  
D Sudheer Kumar
Keyword(s):  
Radiation Therapy ◽  
Adverse Drug Reactions ◽  
Cancer Chemotherapy ◽  
Health Care Professionals ◽  
Private Hospital ◽  
Therapeutic Window ◽  
Pharmacovigilance System ◽  
Drug Reactions ◽  
System Use ◽  
Female Cancer Patients

ABSTRACT Chemotherapy and radiation are one of the important components of treatment for many cancers. Anti-neoplastic agents are used with caution due to their high toxicity and narrow therapeutic window. Studies describing pattern of adverse drug reactions in cancer chemotherapy and radiation therapy patients are less in India. This study aims to evaluate the pattern of ADR’s due to cancer chemotherapy and radiation therapy in hospitalized patients and to assess the causality and severity of these reactions in Telangana state, India. This was a prospective observational study conducted in a private hospital in Telangana region from January to august. Two thousand three hundred and forty two ADR’s were recorded from 254 patients. Most common ADR’s were vomiting (10.7 %), nausea (10.7 %) and fatigue (10.7 %). Majority of the ADR’s (53.5 %) were affecting the Gastro-intestinal system. Naranjo scale for causality assessment showed 54.3 % of the reaction to be “definite”, 36.8 % to be “probable”. Modified Hartwig and Siegel scale for severity showed most reaction (84.1 %) to be of “moderate level”, while 13.3 % of reactions were of “mild level”. There is an immediate need to create awareness among health care professionals regarding the importance of the pharmacovigilance system. Use of preventive measures is to be enhanced in order to reduce the incidence and severity of ADR’s. This study showed most ADR’s are preventable with effective ADR monitoring. Keywords: Adverse drug reaction (ADR), ADR monitoring, Pharmacovigilance, chemotherapy, radiation therapy.

Potential for Conflict of Interest in the Evaluation of Suspected Adverse Drug Reactions

JAMA ◽  
2004 ◽  
Vol 292 (21) ◽  
pp. 2622 ◽  
Author(s):  
Bruce M. Psaty ◽  
Curt D. Furberg ◽  
Wayne A. Ray ◽  
Noel S. Weiss
Keyword(s):  
Adverse Drug Reactions ◽  
Conflict Of Interest ◽  
Drug Reactions ◽  
Suspected Adverse Drug Reactions

scholarly journals Suspected Adverse Drug Reactions Related to Breast Cancer Chemotherapy: Disproportionality Analysis of the Brazilian Spontaneous Reporting System

2019 ◽  
Vol 10 ◽  
Author(s):  
Flávia Campos Barcelos ◽  
Guacira Corrêa de Matos ◽  
Mario Jorge Sobreira da Silva ◽  
Fabrício Alves Barbosa da Silva ◽  
Elisangela da Costa Lima
Keyword(s):  
Breast Cancer ◽  
Adverse Drug Reactions ◽  
Cancer Chemotherapy ◽  
Spontaneous Reporting ◽  
Reporting System ◽  
Spontaneous Reporting System ◽  
Drug Reactions ◽  
Disproportionality Analysis ◽  
Breast Cancer Chemotherapy ◽  
Suspected Adverse Drug Reactions

Pharmacovigilance at the chuk national referral hospital in rwanda: patterns of suspected adverse drug reactions

2015 ◽  
Vol 37 (8) ◽  
pp. e8-e9 ◽  
Author(s):  
E. Rutaganda ◽  
V. Dusabejambo ◽  
J. Nyirigira ◽  
D.R.J. Singer
Keyword(s):  
Adverse Drug Reactions ◽  
Referral Hospital ◽  
Drug Reactions ◽  
Suspected Adverse Drug Reactions ◽  
National Referral Hospital
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