Model-based specific growth rate control forPichia pastoris to improve recombinant protein production

2005 ◽  
Vol 80 (11) ◽  
pp. 1268-1272 ◽  
Author(s):  
Haitao Ren ◽  
Jingqi Yuan
Keyword(s):  
Growth Rate ◽  
Recombinant Protein ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Recombinant Protein Production ◽  
Protein Production ◽  
Specific Growth ◽  
Model Based ◽  
Growth Rate Control

scholarly journals Specific Growth Rate control in Fed-Batch Bakers' Yeast Fermentation

1993 ◽  
Vol 26 (2) ◽  
pp. 185-188
Author(s):  
M. Keulers ◽  
L. Ariaans ◽  
M. Giuseppin ◽  
R. Soeterboek
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Specific Growth ◽  
Yeast Fermentation ◽  
Fed Batch ◽  
Growth Rate Control

Microbial specific growth rate control via MRAC method

1993 ◽  
Vol 24 (11) ◽  
pp. 1973-1985 ◽  
Author(s):  
F. Y. ZENG ◽  
B. DAHHOU ◽  
M. T. NIHTILÄ ◽  
G. GOMA
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Specific Growth ◽  
Growth Rate Control

On-line specific growth rate control for improving reduced glutathione production in Saccharomyces cerevisiae

2015 ◽  
Vol 20 (5) ◽  
pp. 887-893 ◽  
Author(s):  
Zhi-Qiang Xiong ◽  
Mei-Jin Guo ◽  
Ju Chu ◽  
Ying-Ping Zhuang ◽  
Si-Liang Zhang
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Growth Rate ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Specific Growth ◽  
Reduced Glutathione ◽  
On Line ◽  
Growth Rate Control

scholarly journals Robust Adaptive Specific Growth Rate Control in Biotechnological Fed-Batch Processes

2004 ◽  
Vol 37 (3) ◽  
pp. 499-504 ◽  
Author(s):  
E. Picó-Marco ◽  
J. Picó ◽  
H. DeBattista ◽  
J.L. Navarro
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Specific Growth ◽  
Batch Processes ◽  
Fed Batch ◽  
Robust Adaptive ◽  
Growth Rate Control

scholarly journals Practical Solutions for Specific Growth Rate Control Systems in Industrial Bioreactors

Processes ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 693 ◽  
Author(s):  
Galvanauskas ◽  
Simutis ◽  
Levišauskas ◽  
Urniežius
Keyword(s):  
Growth Rate ◽  
Automatic Control ◽  
Specific Growth Rate ◽  
Control Systems ◽  
Rate Control ◽  
Specific Growth ◽  
Physiological State ◽  
Automatic Control Systems ◽  
Biotechnological Processes ◽  
Growth Rate Control

This contribution discusses the main challenges related to successful application of automatic control systems used to control specific growth rate in industrial biotechnological processes. It is emphasized that, after the implementation of basic automatic control systems, primary attention shall be paid to the specific growth rate control systems because this process variable critically affects the physiological state of microbial cultures and the formation of the desired product. Therefore, control of the specific growth rate enables improvement of the quality and reproducibility of the biotechnological processes. The main requirements have been formulated that shall be met to successfully implement the specific growth rate control systems in industrial bioreactors. The relatively easy-to-implement schemes of specific growth rate control systems have been reviewed and discussed. The recommendations for selection of particular control systems for specific biotechnological processes have been provided.

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