Characterization of recombinant monoclonal antibody variants detected by hydrophobic interaction chromatography and imaged capillary isoelectric focusing electrophoresis

2018 ◽  
Vol 1085 ◽  
pp. 96-103 ◽  
Author(s):  
Cory King ◽  
Rekha Patel ◽  
Gomathinayagam Ponniah ◽  
Christine Nowak ◽  
Alyssa Neill ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Isoelectric Focusing ◽  
Hydrophobic Interaction ◽  
Hydrophobic Interaction Chromatography ◽  
Capillary Isoelectric Focusing ◽  
Recombinant Monoclonal Antibody

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

Capillary isoelectric focusing (CIEF) for the characterization of humic substances

1997 ◽  
Vol 31 (8) ◽  
pp. 2037-2049 ◽  
Author(s):  
Ph. Schmitt ◽  
A.W. Garrison ◽  
D. Freitag ◽  
A. Kettrup
Keyword(s):  
Humic Substances ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing
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