scholarly journals One‐pot three‐component 1, 3‐dipolar cycloaddition of azomethineylides to nitrofuran containing acetylenic ketones and molecular docking studies of the cycloadducts

2020 ◽  
Vol 57 (11) ◽  
pp. 3845-3855
Author(s):  
Anish Kumar Kadambar ◽  
Balakrishna Kalluraya ◽  
S. Madan Kumar
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Molecular Docking Studies

scholarly journals A One-Pot Multicomponent Catalytic Synthesis of New 1H-Pyrazole-1-Carbothioamide Derivatives with Molecular Docking Studies as COX-2 Inhibitors

2021 ◽  
Vol 11 (6) ◽  
pp. 13779-13789
Keyword(s):  
Molecular Docking ◽  
Simple Procedure ◽  
Docking Studies ◽  
Catalytic Synthesis ◽  
One Pot ◽  
Reference Drug ◽  
Molecular Docking Studies ◽  
Wide Range ◽  
Cox 2 ◽  
Cox 2 Inhibitors

A simple and efficient catalytic synthesis of new 1H-pyrazole-1-carbothioamide derivatives through a one-pot reaction of hydrazine hydrate, arylidene malononitrile and isothiocyanates in the presence of HAp/ZnCl2 nano-flakes at 60-70°C has been described. The protocol's main advantages include high yields of products, a wide range of substrates, simple procedure, and short reaction time. Molecular docking studies of the designed compounds were accomplished as COX-2 inhibitors and showed that compounds 3d, 3e, 3h, and 3n give promising results compared with celecoxib as a reference drug.

One-pot synthesis, biological evaluation and molecular docking studies of fused thiazolo[2,3-b]pyrimidinone-pyrazolylcoumarin hybrids

2018 ◽  
Vol 22 (4) ◽  
pp. 943-956 ◽  
Author(s):  
Ramesh Gondru ◽  
Saikiran Reddy Peddi ◽  
Vijjulatha Manga ◽  
Manjulatha Khanapur ◽  
Rajitha Gali ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Biological Evaluation ◽  
One Pot ◽  
Molecular Docking Studies ◽  
One Pot Synthesis

Novel carbapenem chalcone derivatives: synthesis, cytotoxicity and molecular docking studies

2015 ◽  
Vol 13 (14) ◽  
pp. 4344-4350 ◽  
Author(s):  
Devendar Reddy Kommidi ◽  
Ramakanth Pagadala ◽  
Surjyakanta Rana ◽  
Parvesh Singh ◽  
Suhas A. Shintre ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Heterogeneous Catalyst ◽  
Docking Studies ◽  
One Pot ◽  
Molecular Docking Studies ◽  
Chalcone Derivatives ◽  
Mcm 41

One-pot efficient synthetic protocol is described for the synthesis of carbapenem chalcone derivatives using AAPTMS@MCM-41 heterogeneous catalyst.

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