A novel 99m
Tc-diester complex as tumor targeting agent: Synthesis, radiolabeling, and biological distribution study

Ideal reaction conditions were found to promote the "cold" monomethylation of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin with CH 3 I , at minute time scale, in the presence of base. The photophysical characterization, cellular uptake and dark cytotoxicity of the resulting monomethylated porphyrin were appraised. Moreover, the syntheses of the corresponding labeled porphyrin, using short-lived carbon-11, prepared in the automated radiolabeling system were efficiently performed. The purification of the labeled product was achieved via preparative HPLC with high radiochemical purity and specific radioactivity. Preliminary studies on the biodistribution of 5,10,15-tris(3-hydroxyphenyl)-20-(3-[11C]methoxyphenyl)porphyrin carried out in a BALB/C normal mouse, using PET imaging, showed that the liver is the main pathway for excretion.

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Distribution of Aedes aegypti and Aedes albopictus in different eco zones of Thiruvananthapuram city with special reference to dengue viremia in humans

ENTOMON ◽

10.33307/entomon.v43i4.402 ◽

2018 ◽

Vol 43 (4) ◽

pp. 223-230

Author(s):

S. Sunil Kumar ◽

D.A. Evans ◽

K. Muthulakshmi ◽

T. DilipKumar ◽

R. Heera Pillai ◽

...

Keyword(s):

Aedes Aegypti ◽

Aedes Albopictus ◽

Dengue Shock Syndrome ◽

Single Step ◽

Equal Distribution ◽

Distribution Study ◽

Urban Zone ◽

High Prevalence ◽

Vector Management ◽

Efficient Vector

Mosquito index study of three ecologically different ecozones of the Thiruvananthapuram district, Kerala showed sharp difference on the proportionate distribution of Aedes aegypti and Aedes albopictus. Human dengue viremia (HDV) was very high in those ecozones where A.aegypti density was high and HDV was low where A.albopictus was high. In a coastal zone of Thiruvananthapuram city, A. aegypti was the most abundant vector and in a hilly, arid suburban zone, A.albopictus was the abundant vector. In the urban zone both species of mosquitoes showed equal distribution. Study on the circulating serotypes in the serum of HDV by Single step single tube Multiplex PCR showed all the four serotypes viz DENV1, DENV2, DENV3 and DENV4 in patients of Thiruvananthapuram city, which indicated the possibility of Dengue Shock Syndrome, unless there is efficient vector management. Among the four dengue serotypes, Type 1 was the most abundant virus. Abundance of microhabitats in Thiruvananthapuram city, which support A. aegypti may be the reason for high prevalence of dengue fever in the urban zone.

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Faculty Opinions recommendation of Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10997956.11937054 ◽

2011 ◽

Author(s):

Rienk Offringa

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Tumor Targeting ◽

Cell Receptor

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Faculty Opinions recommendation of An intein-mediated site-specific click conjugation strategy for improved tumor targeting of nanoparticle systems.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726696016.793522630 ◽

2016 ◽

Author(s):

Morten Meldal ◽

Sanne Schoffelen

Keyword(s):

Tumor Targeting ◽

Site Specific

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Surface Modified Nanoparticulate Carriers for the Targeted Treatment of Breast Cancer

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2015.8.1.2 ◽

2015 ◽

Vol 8 (1) ◽

pp. 2698-2714

Author(s):

Neeraj Mishra ◽

Tejinder Singh ◽

Nidhi ◽

Supandeep Singh Hallan ◽

Veerpal Kaur

Keyword(s):

Breast Cancer ◽

Tumor Targeting ◽

Lipid Nanoparticles ◽

Targeted Treatment ◽

Therapeutic Effects ◽

Target Drug Delivery ◽

Target Drug ◽

Therapeutic Outcomes ◽

Lipid Nanocarriers ◽

Surface Modified

Breast cancer left overs one of the greatest common metastasis disease in females. Advanced diagnostic devices and better understanding of tumour biology can extend the better therapeutic outcomes. Nanotechnology is a tool that helps in cancer diagnosis and treatment therapy. Many nanocarriers such as solid lipid nanoparticles, magnetic nanoparticles, nanocrystals, nanogels, nano-lipid nanocarriers, biodegradable nanoparticles, liposomes, and dendrimers are introduced to improve the therapeutic efficacy of antineoplastic agents. Surface modified target drug delivery system has the potential to increase the therapeutic effects and also reduce the cytotoxicity of breast cancer. Different approaches have been explored for treatment of breast cancer. This review describes the recent advances in the development of nanocarriers used for the targeted treatment of breast cancer. It also focuses on etiology, risk factor and conventional therapy of breast cancer. KEYWORDS: Breast Cancer; Nano-carriers; Tumor Targeting; Ligands; Receptor.

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