Phagocytic function of Kupffer cells in mouse nonalcoholic fatty liver disease models: Evaluation with superparamagnetic iron oxide

2014 ◽  
Vol 41 (5) ◽  
pp. 1218-1227 ◽  
Author(s):  
Hyunhee Cheong ◽  
Seung Soo Lee ◽  
Jin Seong Lee ◽  
Jihoon Kim ◽  
Seong Who Kim ◽  
...  
2014 ◽  
Vol 13 (5) ◽  
pp. 489-495 ◽  
Author(s):  
Zhang Wenfeng ◽  
Wu Yakun ◽  
Mu Di ◽  
Gong Jianping ◽  
Wu Chuanxin ◽  
...  

Hepatology ◽  
2013 ◽  
Vol 59 (1) ◽  
pp. 130-142 ◽  
Author(s):  
Jinghong Wan ◽  
Merieme Benkdane ◽  
Fatima Teixeira-Clerc ◽  
Stéphanie Bonnafous ◽  
Alexandre Louvet ◽  
...  

2012 ◽  
Vol 142 (5) ◽  
pp. S-929
Author(s):  
Maria E. Inzaugarat ◽  
Marianela Ballesta ◽  
Placida Baz ◽  
Dario V. Fontana ◽  
Milagros L. Linares ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Nádia Duarte ◽  
Inês C. Coelho ◽  
Rita S. Patarrão ◽  
Joana I. Almeida ◽  
Carlos Penha-Gonçalves ◽  
...  

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.


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