Temporal assessment of pancreatic blood flow and perfusion following secretin stimulation using noninvasive MRI

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.

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Studies of pharmacological effects on pancreatic blood flow and its application to pancreatic angiography

Gastroenterologia Japonica ◽

10.1007/bf02827188 ◽

1968 ◽

Vol 3 (2) ◽

pp. 130-130 ◽

Cited By ~ 3

Author(s):

A. Kuroda ◽

Y. Ishihara ◽

Y. Kobayashi ◽

H. Shimizu ◽

K. Uegaki

Keyword(s):

Blood Flow ◽

Pharmacological Effects ◽

Pancreatic Blood Flow

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Alloxan, but not streptozotocin, increases blood perfusion of pancreatic islets in rats

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1992.263.1.e57 ◽

1992 ◽

Vol 263 (1) ◽

pp. E57-E63 ◽

Cited By ~ 3

Author(s):

L. Jansson ◽

S. Sandler

Keyword(s):

Blood Flow ◽

Superoxide Dismutase ◽

Vascular System ◽

Flow Distribution ◽

Blood Perfusion ◽

Perfused Pancreas ◽

Pancreatic Blood Flow ◽

Acute Effects ◽

Adult Rats ◽

Stimulation Of

It has recently been shown that selective B-cell toxins alloxan and streptozotocin (STZ) possess marked effects also on the vascular system. To evaluate to what extent changes in blood perfusion of islets induced by alloxan or STZ could be of importance for diabetogenic action of these compounds, we first investigated acute effects of alloxan (75 mg/kg body wt iv) and STZ (40 mg/kg body wt iv) on both whole pancreatic blood flow (PBF) and islet blood flow (IBF) in adult rats. Alloxan caused a marked increase in IBF, which was most pronounced 3 min after administration and remained for 30 min. PBF, however, was decreased 3 min after alloxan administration but was similar to that of control animals from 10 min and onward. These two opposite effects on IBF and PBF caused the fraction of whole PBF diverted through islets to increase from approximately 10 to 50%. Pretreatment with glucose (2 g/kg body wt iv), indomethacin (3.5 mg/kg body wt iv), dimethyl sulfoxide (10 ml/kg body wt ip of a 33% solution), superoxide dismutase (SOD, 1,000 kU/kg body wt iv), NG-methyl-L-arginine (30 mg/kg body wt iv), theophylline (7 mg/kg body wt iv), or terbutaline (1 mg/kg body wt iv) failed to affect stimulation of IBF by alloxan observed at 3 min. SOD was found to exert a marked stimulation of IBF both when given alone and together with alloxan. Alloxan increased IBF and decreased PBF also in a syngeneic pancreaticoduodenal graft in rats but did not affect flow distribution in a perfused pancreas-duodenum preparation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Measurement of pancreatic blood flow in dog by133Xe clearance technique

Pflügers Archiv - European Journal of Physiology ◽

10.1007/bf00587738 ◽

1974 ◽

Vol 348 (1) ◽

pp. 51-57 ◽

Cited By ~ 13

Author(s):

Meral T. Ercan ◽

Naci M. Bor ◽

Co?kun F. Bekdik ◽

G�lsen �ner

Keyword(s):

Blood Flow ◽

Pancreatic Blood Flow ◽

Clearance Technique

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The effect of hypoxia and hypercapnia on canine pancreatic blood flow

Journal of Surgical Research ◽

10.1016/0022-4804(79)90118-5 ◽

1979 ◽

Vol 27 (2) ◽

pp. 114-118 ◽

Cited By ~ 5

Author(s):

Thomas A. Broadie ◽

Mohandas Devedas ◽

Joseph Rysavy ◽

Arnold S. Leonard ◽

John P. Delaney

Keyword(s):

Blood Flow ◽

Pancreatic Blood Flow

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Effect of central thyrotropin-releasing hormone on pancreatic blood flow in rats

Regulatory Peptides ◽

10.1016/j.regpep.2004.04.006 ◽

2004 ◽

Vol 121 (1-3) ◽

pp. 57-63 ◽

Cited By ~ 6

Author(s):

Manabu Goto ◽

Masashi Yoneda ◽

Kimihide Nakamura ◽

Akira Terano ◽

Masakazu Haneda

Keyword(s):

Blood Flow ◽

Thyrotropin Releasing Hormone ◽

Pancreatic Blood Flow ◽

Releasing Hormone

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Utility of Contrast-Enhanced Transabdominal Ultrasonography to Diagnose Early Chronic Pancreatitis

BioMed Research International ◽

10.1155/2015/393124 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Nobuaki Azemoto ◽

Teru Kumagi ◽

Tomoyuki Yokota ◽

Masashi Hirooka ◽

Taira Kuroda ◽

...

Keyword(s):

Blood Flow ◽

Chronic Pancreatitis ◽

Mesenteric Artery ◽

Region Of Interest ◽

Pancreatic Blood Flow ◽

Transabdominal Ultrasonography ◽

Pancreatic Parenchyma ◽

Contrast Enhanced ◽

And Control ◽

The Relationship

Purpose. The purpose of this study was to establish the relationship between the grade of chronic pancreatitis (CP) and pancreatic blood flow as measured by contrast-enhanced transabdominal ultrasonography (CEUS) and to diagnose early CP easily.Methods. This pilot study was conducted in 8 patients with CP, 7 patients with early CP, and 6 control participants. After injecting 0.015 mL/kg of perflubutane by manual bolus, values in one region of interest (ROI) in pancreatic parenchyma and one ROI including the superior mesenteric artery (SMA) were measured.Results. The ratio of blood flow in the SMA and pancreatic parenchyma increased with grade of CP and was significantly higher in patients with CP (5.41; 2.10–11.02) than in patients with early CP (2.46; 1.41–5.05) and control participants (2.32; 1.25–3.04)(P=0.0279,P=0.0142, resp.). The ratio of blood flow in the SMA and pancreatic parenchyma correlated with grade of CP(rs=0.5904,P=0.0048).Conclusion. The ratio of blood flow correlates with grade of CP on CEUS. This safe and convenient method may be useful to diagnose early CP.

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