Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia

Two (2·3 %) of 87 wild-caught boars in Japan had detectable hepatitis E virus (HEV) RNA. The two boar HEV isolates (wbJTS1 and wbJYG1) obtained in the present study and a previously reported isolate (wbJSG1) whose partial sequence had been determined were sequenced over the entire genome. The wbJSG1, wbJTS1 and wbJYG1 isolates comprised 7225 or 7226 nt, excluding the poly(A) tail, and segregated into genotype 3. They differed by 8·5–11·2 % from each other and by 8·6–18·4 % from 17 reported genotype 3 HEV isolates, including one boar isolate, in the full-length sequence. When compared with 191 reported genotype 3 HEV isolates whose partial sequences were known, these three boar isolates were closer to Japanese isolates than to isolates of non-Japanese origin (89·2±2·6 vs 85·9±2·2 %; P<0·0001). A proportion of wild boars in Japan are infected with markedly heterogeneous HEV strains that are indigenous to Japan and may serve as reservoirs of HEV.

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Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan

Virus Research ◽

10.1016/j.virusres.2017.08.003 ◽

2017 ◽

Vol 240 ◽

pp. 147-153 ◽

Cited By ~ 2

Author(s):

Putu Prathiwi Primadharsini ◽

Masao Miyake ◽

Satoshi Kunita ◽

Tsutomu Nishizawa ◽

Masaharu Takahashi ◽

...

Keyword(s):

Virus Strain ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Full Length ◽

Genotype 3 ◽

Domestic Pigs ◽

Novel Genotype ◽

Full Length Genome

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Hepatitis E virus genotyping based on full-length genome and partial genomic regions

Virus Research ◽

10.1016/j.virusres.2006.01.013 ◽

2006 ◽

Vol 120 (1-2) ◽

pp. 57-69 ◽

Cited By ~ 83

Author(s):

Lijie Zhai ◽

Xing Dai ◽

Jihong Meng

Keyword(s):

Hepatitis E Virus ◽

Hepatitis E ◽

Full Length ◽

Genomic Regions ◽

Full Length Genome

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Genome-Wide Comparisons of Phylogenetic Similarities between Partial Genomic Regions and the Full-Length Genome in Hepatitis E Virus Genotyping

PLoS ONE ◽

10.1371/journal.pone.0115785 ◽

2014 ◽

Vol 9 (12) ◽

pp. e115785 ◽

Cited By ~ 6

Author(s):

Shuai Wang ◽

Wei Wei ◽

Xuenong Luo ◽

Xuepeng Cai

Keyword(s):

Hepatitis E Virus ◽

Hepatitis E ◽

Full Length ◽

Genome Wide ◽

Genomic Regions ◽

Full Length Genome

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Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan

Journal of Medical Virology ◽

10.1002/jmv.24743 ◽

2016 ◽

Vol 89 (6) ◽

pp. 1116-1120 ◽

Cited By ~ 12

Author(s):

Masahito Miura ◽

Jun Inoue ◽

Mio Tsuruoka ◽

Tsutomu Nishizawa ◽

Shigeo Nagashima ◽

...

Keyword(s):

Sequence Analysis ◽

Acute Hepatitis ◽

Hepatitis E Virus ◽

Genomic Sequence ◽

Hepatitis E ◽

Full Length ◽

Nucleotide Identity ◽

Genomic Sequence Analysis ◽

Virus Isolates

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Complete Genome Sequences of Two Swiss Hepatitis E Virus Isolates from Human Stool and Raw Pork Sausage

Genome Announcements ◽

10.1128/genomea.00888-17 ◽

2017 ◽

Vol 5 (35) ◽

Cited By ~ 11

Author(s):

Jakub Kubacki ◽

Cornel Fraefel ◽

Marco Jermini ◽

Petra Giannini ◽

Gladys Martinetti ◽

...

Keyword(s):

Hepatitis E Virus ◽

Hepatitis E ◽

Genotype 3 ◽

Genome Sequences ◽

Virus Genotype ◽

Pig Liver ◽

Pork Sausage ◽

Full Length Genome ◽

Virus Isolates ◽

Human Stool

ABSTRACT We present here the full-length genome sequences of two hepatitis E virus genotype 3 (HEV-3) isolates from a human stool sample from a patient with acute hepatitis and a raw sausage containing pig liver. Sequence analysis implies that Swiss HEV isolates may form a novel subgroup of HEV-3 viruses.

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