Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia

2003 ◽  
Vol 72 (4) ◽  
pp. 461-471 ◽  
Author(s):  
Tsutomu Sasaki ◽  
Kazuo Kitagawa ◽  
Shiro Sugiura ◽  
Emi Omura-Matsuoka ◽  
Shigeru Tanaka ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Adult Mouse ◽  
Neural Progenitor ◽  
Cyclooxygenase 2 ◽  
Mouse Hippocampus

Dopamine D2 receptor stimulation promotes the proliferation of neural progenitor cells in adult mouse hippocampus

Neuroreport ◽  
2007 ◽  
Vol 18 (7) ◽  
pp. 659-664 ◽  
Author(s):  
Takeshi Hiramoto ◽  
Yasunari Kanda ◽  
Yasushi Satoh ◽  
Kunio Takishima ◽  
Yasuhiro Watanabe
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Adult Mouse ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Neural Progenitor ◽  
Receptor Stimulation ◽  
Dopamine D2 ◽  
Mouse Hippocampus

Trehalose as glucose surrogate in proliferation and cellular mobility of adult neural progenitor cells derived from mouse hippocampus

2019 ◽  
Vol 126 (11) ◽  
pp. 1485-1491
Author(s):  
Alexandra Bertl ◽  
Victor Brantl ◽  
Norbert Scherbaum ◽  
Dan Rujescu ◽  
Jens Benninghoff
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Mouse Hippocampus

scholarly journals Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Shu-Min Chou ◽  
Ke-Xin Li ◽  
Ming-Yueh Huang ◽  
Chao Chen ◽  
Yuan-Hung Lin King ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Progenitor Cells ◽  
Molecular Mechanisms ◽  
Neural Progenitor Cells ◽  
Multinomial Logistic Regression ◽  
Neural Progenitor ◽  
Cell Renewal ◽  
Postnatal Neurogenesis ◽  
Stem Cell Renewal ◽  
Mouse Hippocampus

In the postnatal brain, neurogenesis occurs only within a few regions, such as the hippocampal sub-granular zone (SGZ). Postnatal neurogenesis is tightly regulated by factors that balance stem cell renewal with differentiation, and it gives rise to neurons that participate in learning and memory formation (Anacker and Hen, 2017; Bond et al., 2015; Toda et al., 2019). The Kv1.1 channel, a voltage-gated potassium channel, was previously shown to suppress postnatal neurogenesis in the SGZ in a cell-autonomous manner. In this study, we clarified the physiological and molecular mechanisms underlying Kv1.1-dependent postnatal neurogenesis. First, we discovered that the membrane potential of neural progenitor cells is highly dynamic during development. We further established a multinomial logistic regression model for cell type classification based on the biophysical characteristics and corresponding cell markers. We found that loss of Kv1.1 channel activity causes significant depolarization of type 2b neural progenitor cells. This depolarization is associated with increased tropomyosin receptor kinase B (TrkB) signaling and proliferation of neural progenitor cells; suppressing TrkB signaling reduces the extent of postnatal neurogenesis. Thus, our study defines the role of the Kv1.1 potassium channel in regulating the proliferation of postnatal neural progenitor cells in the mouse hippocampus.

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