Cannabinoid agonist WIN55,212-2 induces apoptosis in cerebellar granule cells via activation of the CB1 receptor and downregulation of bcl-xL gene expression

2006 ◽  
Vol 83 (6) ◽  
pp. 1058-1065 ◽  
Author(s):  
Giacomo Pozzoli ◽  
Giuseppe Tringali ◽  
Mauro Vairano ◽  
Monia D'Amico ◽  
Pierluigi Navarra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cb1 Receptor ◽  
Cerebellar Granule ◽  
Cannabinoid Agonist

Conservation of γ-Aminobutyric Acid Type A Receptor α6 Subunit Gene Expression in Cerebellar Granule Cells

2002 ◽  
Vol 66 (5) ◽  
pp. 1810-1818 ◽  
Author(s):  
Sabine Bahn ◽  
Robert J. Harvey ◽  
Mark G. Darlison ◽  
William Wisden
Keyword(s):  
Gene Expression ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Type A ◽  
Aminobutyric Acid ◽  
Subunit Gene ◽  
Cerebellar Granule ◽  
Acid Type

scholarly journals The Expression of the PDZ Protein MALS-1/Velis Is Regulated by Calcium and Calcineurin in Cerebellar Granule Cells

2002 ◽  
Vol 277 (51) ◽  
pp. 49585-49590 ◽  
Author(s):  
Bastiano Sanna ◽  
Dana Kramer ◽  
Armando A. Genazzani
Keyword(s):  
Gene Expression ◽  
Neuronal Development ◽  
Granule Cells ◽  
De Novo ◽  
Cerebellar Granule Cells ◽  
Transcriptional Level ◽  
Synaptic Density ◽  
Cerebellar Granule ◽  
Activity Dependent ◽  
Post Synaptic Density

Activity-dependent gene expression is thought to be important in shaping neuronal development and in modifying the protein content of neurons. Ca2+entry into neurons appears to be one of the key effectors of activity-dependent gene expression. Among the possible downstream targets of calcium, the protein phosphatase calcineurin represents a prime candidate. We hereby report that in cultured cerebellar granule cells the activation of the Ca2+/calcineurin pathway via either voltage- or ligand- operated Ca2+channels regulates MALS-1 and MALS-2 expression at the transcriptional level. These proteins are integral parts of the post-synaptic density and are also involved in receptor trafficking. MALS regulation is not at the level of mRNA stability and does not requirede novoprotein synthesis, thereby suggesting a direct pathway. These data suggest that Ca2+entry by means of calcineurin is capable of controlling the structure of the post-synaptic density by controlling the expression of key components at the transcriptional level.

98 Gene expression of transcription factors in apoptotic cerebellar granule cells

1996 ◽  
Vol 14 ◽  
pp. 74-74
Author(s):  
D.F. Condorelli ◽  
A. Copani ◽  
A. Calogero ◽  
P. Dell'Albani ◽  
F. Nicoletti ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule

The absence of pleiotrophin modulates gene expression in the hippocampus in vivo and in cerebellar granule cells in vitro

2016 ◽  
Vol 75 ◽  
pp. 113-121 ◽  
Author(s):  
Celia González-Castillo ◽  
Daniel Ortuño-Sahagún ◽  
Carolina Guzmán-Brambila ◽  
Ana Laura Márquez-Aguirre ◽  
Rita Raisman-Vozari ◽  
...  
Keyword(s):  
Gene Expression ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule

Fragment 31–35 of β-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation

2006 ◽  
Vol 49 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Francesco Misiti ◽  
M. Elisabetta Clementi ◽  
Giuseppe Tringali ◽  
Mauro Vairano ◽  
Federica Orsini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Caspase 3 ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Amyloid Peptide ◽  
Cerebellar Granule ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Bax Gene
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