Microinjury to the synovial membrane may cause disaggregation of proteoglycans in rabbit knee joint articular cartilage

1984 ◽  
Vol 2 (3) ◽  
pp. 207-220 ◽  
Author(s):  
Linda Frost ◽  
Peter Ghosh
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Synovial Membrane ◽  
Rabbit Knee

The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint

2004 ◽  
Vol 82 (7) ◽  
pp. 502-505 ◽  
Author(s):  
Nazim Dogan ◽  
Ali Fuat Erdem ◽  
Cemal Gundogdu ◽  
Husnu Kursad ◽  
Mehmet Kizilkaya
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Synovial Membrane ◽  
Inflammatory Cell ◽  
Inflammatory Cell Infiltration ◽  
Knee Joints ◽  
Cell Infiltration ◽  
Histopathological Changes ◽  
Rabbit Knee ◽  
Group I

Analgesics are commonly injected intra-articularly for analgesia after arthroscopic surgery, especially of knee joints. The aim of this study was to research the effects of ketorolac and morphine on articular cartilage and synovial membrane. This study used rabbit right and left hind knee joints. The treatments, saline, morphine, or ketorolac, were administered intra-articularly 24 h after injection, and 5 joints from animals in each drug group were chosen randomly to form Group I and subgroups of Group I. The same procedures were applied after 48 h and 10 days of injection to form Groups II and III, respectively, and subgroups of these groups. Knee joints were excised and a blinded observer evaluated the histopathology according to inflammation of the articular cartilage, inflammatory cell infiltration, hypertrophy, and hyperplasia of the synovial membrane. No histopathological changes were found in the control groups. In the ketorolac and morphine groups, there were varying degrees of synovial membrane inflammatory cell infiltration and minimal, mild, or moderate synovial membrane cell hyperplasia or hypertrophy. Except for the ketorolac group at 24 h, both ketorolac and morphine groups showed more histopathological changes than controls (p < 0.05). Morphine and ketorolac both cause mild histopathological changes in rabbit knee joints, morphine causing more than ketorolac, but both of the drugs can be used intra-articularly with safety.Key words: intra-articular analgesia, knee joint, histopathological changes, articular cartilage, synovial membrane.

Effects of Osmium Tetroxide on the Rabbit Knee Joint Normal Synovial Membrane

1987 ◽  
Vol 16 (1) ◽  
pp. 121-129
Author(s):  
M. Möttönen ◽  
M. Pantio ◽  
T. Nevalainen
Keyword(s):  
Knee Joint ◽  
Synovial Membrane ◽  
Osmium Tetroxide ◽  
Rabbit Knee

Meniscus and Synovial Membrane: An Electronmicroscopic Study on Rabbits

2001 ◽  
Vol 26 (3) ◽  
pp. 254-260 ◽  
Author(s):  
S.Y. Hu ◽  
S. Wang ◽  
R.T. Zuo ◽  
K.L. Wang ◽  
L. Qin
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Surface Morphology ◽  
Synovial Membrane ◽  
Femoral Condyle ◽  
Joint Capsule ◽  
Cartilage Surface ◽  
Articular Cartilage Surface ◽  
Scanning Electronmicroscopy ◽  
Transmission Electronmicroscopy

Seven healthy mature rabbits were used to study both the surface morphology of the meniscus using both transmission electronmicroscopy (TEM) and scanning electronmicroscopy (SEM) and articular cartilage of the femoral condyle using SEM. Results showed that the membrane covering the meniscus was structurally the extension of synovial membrane of the knee joint capsule. Additionally, the presence of canal-like openings over the membranous surface to the meniscus was noted, which were absent over the articular cartilage surface. Key words: transmission and scanning electronmicroscopy, meniscus, articular cartilage, rabbits

Site-specific cell-tissue interactions in rabbit knee joint articular cartilage

2016 ◽  
Vol 49 (13) ◽  
pp. 2882-2890 ◽  
Author(s):  
A.P. Ronkainen ◽  
J.M. Fick ◽  
W. Herzog ◽  
R.K. Korhonen
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Specific Cell ◽  
Site Specific ◽  
Rabbit Knee ◽  
Tissue Interactions ◽  
Cell Tissue

scholarly journals The Possible Therapeutic Role of Platelet Rich Plasma on a Model of Osteoarthritis in Male Albino Rat. Histological and Immunohistochemical Study

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
N Gamal ◽  
N M Abourabia ◽  
F H Elebiary ◽  
G Khalaf ◽  
M H Raafat
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Rat Model ◽  
Synovial Membrane ◽  
Platelet Rich Plasma ◽  
Knee Joints ◽  
Group I ◽  
Group 15 ◽  
Group Ii ◽  
The Right

Abstract Introduction and Aim of the Study Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and progressive loss of articular cartilage. This study was conducted to evaluate the therapeutic effect of platelet-rich plasma (PRP) of the knee joint in a rat model of OA. Materials and Methods Forty adult male albino rats, weighing 200-250 gms, were used in this study, ten rats used as donors to obtain PRP. The other thirty rats were divided into two main groups. Group I: The control group (15 rats) in which the rats were subdivided into three subgroups. Subgroups IA and IB were sacrificed 4 and 6 weeks after the beginning of the experiment. Subgroup IC left for 4 weeks then received intra-articular injection of PRP in the right knee joint which was repeated three times per week for 2 weeks then the animals were sacrificed. Group II (The experimental group) (15 rats) in which OA was induced by surgical induction of cartilaginous defect in the right knee joints. The rats of group II were subdivided into three subgroups. Subgroups IIA and IIB were sacrificed 4 and 6 weeks after induction of OA respectively. Subgroup IIC received intra-articular injection of PRP (0.2 ml) in the right knee joints 4 weeks after surgery. The injection was repeated three times per week for 2 weeks then the animals were sacrificed. The right joints from all groups were collected, decalcified and processed for histological studies. Specimens were also processed for transmission electron microscopic study. Morphometric and statistical measurements were done. Results Histological examination of the right knee joints of OA (subgroups IIA and IIB) resulted in thickening of the intimal lining of the synovial membrane, cellular infiltration and increased collagen content of the subintima. The articular cartilage showed erosions, thinning of cartilage, chondrocytes and ground substance loss, and moderate expression of platelet derived growth factor (PDGF). Injection of PRP resulted in improvement of the structure of the synovial membrane and the articular cartilage and strong expression of PDGF. Conclusion Intra-articular injection of PRP resulted in a significant improvement in the histological structure of the knee joint in a rat model of OA.

Effects of Osmium Tetroxide on the Rabbit Knee Joint Normal Synovial Membrane

1987 ◽  
Vol 16 (1) ◽  
pp. 121-129
Author(s):  
M. Möttönen ◽  
M. Pantio ◽  
T. Nevalainen
Keyword(s):  
Knee Joint ◽  
Synovial Membrane ◽  
Osmium Tetroxide ◽  
Rabbit Knee

Effects of Osmium Tetroxide on the Rabbit Knee Joint Normal Synovial Membrane

1970 ◽  
Vol 16 (1-4) ◽  
pp. 121-129 ◽  
Author(s):  
M. Möttönen ◽  
M. Pantio ◽  
T. Nevalainen
Keyword(s):  
Knee Joint ◽  
Synovial Membrane ◽  
Osmium Tetroxide ◽  
Rabbit Knee
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