Gene expression of myogenic regulatory factors, nicotinic acetylcholine receptor subunits, and GAP-43 in skeletal muscle following denervation in a rat model

2007 ◽  
Vol 25 (11) ◽  
pp. 1498-1505 ◽  
Author(s):  
Jianjun Ma ◽  
Jian Shen ◽  
Jeffrey P. Garrett ◽  
Cassandra A. Lee ◽  
Zhongyu Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Rat Model ◽  
Myogenic Regulatory Factors ◽  
Nicotinic Acetylcholine ◽  
Regulatory Factors

Gene expression of the nicotinic acetylcholine receptor α4 subunit in the frontal cortex in Parkinson's disease patients

1995 ◽  
Vol 187 (3) ◽  
pp. 173-176 ◽  
Author(s):  
Hannsjörg Schröder ◽  
Robert A.I. de Vos ◽  
Ernst N.H. Jansen ◽  
Christina Birtsch ◽  
Andrea Wevers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Frontal Cortex ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine

Exercise training alters DNA methylation patterns in genes related to muscle growth and differentiation in mice

2015 ◽  
Vol 308 (10) ◽  
pp. E912-E920 ◽  
Author(s):  
Timo Kanzleiter ◽  
Markus Jähnert ◽  
Gunnar Schulze ◽  
Joachim Selbig ◽  
Nicole Hallahan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Dna Methylation ◽  
Exercise Training ◽  
Metabolic Regulation ◽  
Muscle Growth ◽  
Epigenetic Mechanism ◽  
Myogenic Regulatory Factors ◽  
Regulatory Factors ◽  
A Genome

The adaptive response of skeletal muscle to exercise training is tightly controlled and therefore requires transcriptional regulation. DNA methylation is an epigenetic mechanism known to modulate gene expression, but its contribution to exercise-induced adaptations in skeletal muscle is not well studied. Here, we describe a genome-wide analysis of DNA methylation in muscle of trained mice ( n = 3). Compared with sedentary controls, 2,762 genes exhibited differentially methylated CpGs ( P < 0.05, meth diff >5%, coverage >10) in their putative promoter regions. Alignment with gene expression data ( n = 6) revealed 200 genes with a negative correlation between methylation and expression changes in response to exercise training. The majority of these genes were related to muscle growth and differentiation, and a minor fraction involved in metabolic regulation. Among the candidates were genes that regulate the expression of myogenic regulatory factors ( Plexin A2) as well as genes that participate in muscle hypertrophy ( Igfbp4) and motor neuron innervation ( Dok7). Interestingly, a transcription factor binding site enrichment study discovered significantly enriched occurrence of CpG methylation in the binding sites of the myogenic regulatory factors MyoD and myogenin. These findings suggest that DNA methylation is involved in the regulation of muscle adaptation to regular exercise training.

Sign in / Sign up

Export Citation Format

Share Document