scholarly journals Lumbar disc degeneration is an equally important risk factor as lumbar fusion for causing adjacent segment disc disease

2016 ◽  
Vol 35 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Raghu N. Natarajan ◽  
Gunnar B.J. Andersson
Author(s):  
Lissette M. Ruberté ◽  
Raghu Natarajan ◽  
Gunnar B. J. Andersson

Degenerative disc disease (DDD) is a progressive pathological condition observed in 60 to 80% of the population [1]. It involves changes in both the biochemistry and morphology of the intervertebral disc and is associated with chronic low back pain, sciatica and adult scoliosis [2,3]. The most accepted theory of the effects of DDD on the kinematics of the spine is that proposed by Kirkaldy-Willis and Farfan which states that the condition initiates as a temporary dysfunction, followed by instability and then re-stabilization as the disease progresses [4]. Although there is no clear relationship between disc degeneration and the mechanical behavior of the lumbar spine, abnormal motion patterns either in the form of increased motion or erratic motion have been reported from studies on human cadaveric motion segments [5,6]. To date however no study has looked at how disc degeneration affects the adjacent segment mechanics. IN vivo testing is difficult for these purposes given that specimens are generally obtained from people at the later stages of life and consequently often display multiple pathologies. A finite element model is a viable alternative to study the mechanics of the segments adjacent to the diseased disc. It is hypothesized that moderate degeneration at one level will alter the kinematics of the whole lumbar spine.


2014 ◽  
Vol 14 (6) ◽  
pp. 925-932 ◽  
Author(s):  
Peter Bernstein ◽  
Susanne Hentschel ◽  
Ivan Platzek ◽  
Sebastian Hühne ◽  
Uwe Ettrich ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Fadi Taher ◽  
David Essig ◽  
Darren R. Lebl ◽  
Alexander P. Hughes ◽  
Andrew A. Sama ◽  
...  

Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine, but novel treatment strategies involving stem cells, growth factors, and gene therapy have the theoretical potential to prevent, slow, or even reverse disc degeneration. Understanding the pathophysiological basis of disc degeneration is essential for the development of treatment strategies that target the underlying mechanisms of disc degeneration rather than the downstream symptom of pain. Such strategies ideally aim to induce disc regeneration or to replace the degenerated disc. However, at present, treatment options for degenerative disc disease remain suboptimal, and development and outcomes of novel treatment options currently have to be considered unpredictable.


2013 ◽  
Vol 7 (1) ◽  
pp. 258-263 ◽  
Author(s):  
Anne Froholdt ◽  
Jens Ivar Brox ◽  
Olav Reikerås ◽  
Gunnar Leivseth

Purpose: To compare lumbar disc degeneration at 9-year follow-up in patients with chronic low back pain who had instrumented lumbar fusion or no fusion. Material and methodology: The main outcomes were disc height and sagittal alignment measured by Distortion Compensated Roentgen Analysis (DCRA). Secondary outcome included the Oswestry Disability Index and VAS back pain. Results: Forty-eight patients with baseline and 9-year radiographs from L2- S1 were included. Twenty-three had lumbar fusion and 25 had no fusion. Disc height was reduced at all levels independent of fusion. No difference in disc height and sagittal alignment was observed between patients fused and not fused. There were weak correlations, ranging from 0.04 to 0.36, between clinical and radiological parameters. Conclusion: Lumbar disc degeneration increased at all measured levels independent of fusion and correlated poorly with clinical outcome.


2018 ◽  
Vol 36 (9) ◽  
pp. 2469-2475 ◽  
Author(s):  
Yitao Wang ◽  
Hongli Wang ◽  
Feizhou Lv ◽  
Xiaosheng Ma ◽  
Xinlei Xia ◽  
...  

2011 ◽  
Vol 16 (2) ◽  
pp. 8-9
Author(s):  
Marjorie Eskay-Auerbach

Abstract The incidence of cervical and lumbar fusion surgery has increased in the past twenty years, and during follow-up some of these patients develop changes at the adjacent segment. Recognizing that adjacent segment degeneration and disease may occur in the future does not alter the rating for a cervical or lumbar fusion at the time the patient's condition is determined to be at maximum medical improvement (MMI). The term adjacent segment degeneration refers to the presence of radiographic findings of degenerative disc disease, including disc space narrowing, instability, and so on at the motion segment above or below a cervical or lumbar fusion. Adjacent segment disease refers to the development of new clinical symptoms that correspond to these changes on imaging. The biomechanics of adjacent segment degeneration have been studied, and, although the exact mechanism is uncertain, genetics may play a role. Findings associated with adjacent segment degeneration include degeneration of the facet joints with hypertrophy and thickening of the ligamentum flavum, disc space collapse, and translation—but the clinical significance of these radiographic degenerative changes remains unclear, particularly in light of the known presence of abnormal findings in asymptomatic patients. Evaluators should not rate an individual in anticipation of the development of changes at the level above a fusion, although such a development is a recognized possibility.


1990 ◽  
Vol 31 (6) ◽  
pp. 551-554
Author(s):  
O. Tervonen ◽  
S. Lahde ◽  
J. Rydberg

Author(s):  
Saeeda Baig

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.


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