scholarly journals Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury

2017 ◽  
Author(s):  
Deva D. Chan ◽  
Jun Li ◽  
Wei Luo ◽  
Dan N. Predescu ◽  
Brian J. Cole ◽  
...  
Keyword(s):  
Bone Loss ◽  
Subchondral Bone ◽  
Cartilage Injury ◽  
Knee Cartilage

Diagnostic Imaging of Knee Cartilage Injury: Evaluation and Assessment

2020 ◽  
pp. 195-213
Author(s):  
Gaurav K. Thawait ◽  
Gustav Andreisek ◽  
Avneesh B. Chhabra
Keyword(s):  
Diagnostic Imaging ◽  
Cartilage Injury ◽  
Knee Cartilage ◽  
Evaluation And Assessment

scholarly journals Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon-to-Bone Insertion Site Failure Properties

2020 ◽  
Vol 142 (11) ◽  
Author(s):  
Ashley K. Fung ◽  
Snehal S. Shetye ◽  
Yihan Li ◽  
Yilu Zhou ◽  
X. Sherry Liu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Loss ◽  
Subchondral Bone ◽  
Bone Mineralization ◽  
Insertion Site ◽  
Supraspinatus Tendon ◽  
Bone Microstructure ◽  
Female Rats ◽  
Pregnancy And Lactation ◽  
Failure Properties

Abstract Pregnant women experience weight gain, gait changes, and biochemical fluctuations that impair joint function and alter the maternal skeleton. Hormonal changes increase pelvic ligament laxity in preparation for childbirth and affect peripheral joint laxity. Calcium demands also rise during pregnancy and lactation, resulting in reduced bone mineral density (BMD) and maternal bone loss. Altered tendon properties and bone loss during pregnancy and lactation may impact tendon insertion sites, such as rotator cuff tendons where insertion site ruptures are common. However, the effects of pregnancy and lactation at the tendon-to-bone interface have not been investigated. Therefore, the objective of this study was to evaluate supraspinatus tendon mechanical properties and insertion site microstructure during pregnancy, lactation, and postweaning recovery in female rats. We hypothesized that pregnancy and lactation would compromise supraspinatus tendon mechanical properties and subchondral bone microstructure. Female rats were divided into virgin, pregnancy, lactation, and recovery groups, and supraspinatus tendons were mechanically evaluated. Surprisingly, tendon mechanics was unaffected by pregnancy and lactation. However, tendon modulus decreased two-weeks postweaning. Additionally, tendons failed by bony avulsion at the insertion site, and the lactation group exhibited reduced failure properties corresponding to decreased subchondral bone mineralization. Lactation also resulted in dramatic bone loss at the epiphysis, but trabecular bone microarchitecture recovered postweaning. In conclusion, lactation following pregnancy impaired trabecular bone microstructure and subchondral bone mineralization, leading to reduced supraspinatus tendon-to-bone insertion site failure properties. These findings will contribute toward understanding the pathogenesis of tendon-to-bone disorders.

Doxycycline effects on mechanical and morphometrical properties of early- and late-stage osteoarthritic bone following anterior cruciate ligament injury

2004 ◽  
Vol 97 (4) ◽  
pp. 1254-1260 ◽  
Author(s):  
Connor K. Pardy ◽  
John R. Matyas ◽  
Ronald F. Zernicke
Keyword(s):  
Anterior Cruciate Ligament ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Subchondral Bone ◽  
Bone Structure ◽  
Femoral Condyle ◽  
Cruciate Ligament ◽  
Ligament Injury ◽  
Doxycycline Treatment ◽  
Anterior Cruciate

As posttraumatic osteoarthritis (OA) progresses, the mechanical and morphometrical properties of the subchondral bone change and may be linked to damage of the articular cartilage. Potentially to slow that progression, doxycycline was administered orally twice daily (4 mg·kg−1·day−1) in skeletally mature canines after anterior cruciate ligament transection (ACLX). To test if doxycycline significantly altered the structure and function of OA bone, we tested cancellous bone mechanical properties, measured bone mineral content, and analyzed bone structure by microcomputed tomography. Our investigation focused on subchondral trabecular bone changes in the medial femoral condyle at 36 and 72 wk after ACLX. Significant mechanical changes discovered at 36 wk post-ACLX were less obvious at 72 wk in both treated and ACLX groups. Doxycycline treatment conserved bone strain energy density at 72 wk. Doxycycline had little effect on the degradation of superficial osseous tissue at 36 wk post-ACLX; by 72 wk, doxycycline in an ACLX model limited subchondral bone loss within the first 3 mm of periarticular bone with established OA. Significant bone loss occurred in the deeper trabecular bone for all groups. Substantial architectural adaptation within deeper trabecular bone accompanied changes in mechanics in early and established OA.

scholarly journals Longitudinal assessment of cartilage composition by high-field MRI in patients with low-grade knee cartilage injury

2019 ◽  
Vol 27 ◽  
pp. S335
Author(s):  
C. Scotti ◽  
D. Laurent ◽  
V. Juras ◽  
V. Mlynarik ◽  
M. Schreiner ◽  
...  
Keyword(s):  
High Field ◽  
Cartilage Injury ◽  
Low Grade ◽  
Longitudinal Assessment ◽  
Knee Cartilage ◽  
High Field Mri

Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats

Bone ◽  
2011 ◽  
Vol 48 (2) ◽  
pp. 362-371 ◽  
Author(s):  
Kai Jiao ◽  
Li-Na Niu ◽  
Mei-Qing Wang ◽  
Juan Dai ◽  
Shi-Bin Yu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Subchondral Bone ◽  
Cartilage Degradation
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