A semiautomated method to quantitatively assess osteolytic lesion volume and bone mineral density within acetabular regions of interest from CT

SummaryThe objective was to determine signalment-related differences in bone mineral content (BMC) and bone mineral density (BMD) in dogs. Unilateral appendicular bones were harvested from 62 canine cadavers. Middiaphyseal regions of interest (ROIs) were scanned using a Hologic® DXA device Braincon, Vienna, Austria). BMC and BMD were calculated within this region. Middle-aged dogs (3 . 10 years) revealed the highest BMC and BMD levels. Mean BMC and BMD were higher in males compared to females. Furthermore, bodyweight of the male dogs was significantly higher compared to the females (P<0.0001). Body weight and bone length were significantly associated with BMC and BMD (P.0.023) in all bones but the radius. These data suggest that BMC and BMD appear to be highest in male large-breed dogs with a body weight greater than 30 kg. These results may help determine risk factors in fracture development and healing.

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Quantitative measurements of adaptive bone remodeling around the cemented Zimmer® segmental stem after tumor resection arthroplasty using dual-energy x-ray absorptiometry

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04395-2 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Christina Enciso Holm ◽

Peter Horstmann ◽

Michala Skovlund Sørensen ◽

Karen Dyreborg ◽

Michael Mørk Petersen

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Metastatic Bone Disease ◽

Regions Of Interest ◽

Trabecular Metal ◽

Mineral Density ◽

X Ray ◽

Tumor Prosthesis ◽

Cemented Stem

Abstract Background Limb salvage surgery (LSS) is the preferred method for treatment of patients with sarcomas and to a greater extent also to patients with metastatic bone disease. The aim of the present study was to evaluate the adaptive remodeling of the periprosthetic cortical bone after insertion of a tumor prosthesis with cemented stem. Methods A prospective study of 21 patients (F/M = 12/9), mean age 55 years (range 15–81) with metastatic bone disease (n = 9), sarcomas (n = 8) or aggressive benign tumors (n = 4) who underwent bone resection due to a tumor, and reconstruction with a tumor-prosthesis (Zimmer® Segmental 130 mm straight fluted cemented stem with trabecular metal (TM) collars) in the proximal femur (n = 10), distal femur (n = 9) or proximal tibia (n = 2). Measurements of bone mineral density (BMD) (g/cm2) were done postoperatively and after 3, 6, and 12 months using dual-energy X-ray absorptiometry. BMD was measured in 4 regions of interest around the cemented stem and in one region of interest 1 cm proximal from the ankle joint of the affected limb and measurement of the contralateral ankle was used as reference. Repeated measures ANOVA and students paired t-test was used to evaluate BMD changes over time. Results At 1-year follow-up, BMD decreased compared to baseline in all four regions of interest with a statistically significant bone loss of 8–15%. The bone loss was most pronounced (14–15%) in the 2 regions of interest closest to the trabecular metal (TM) collar and lowest (8%) adjacent to the tip of the stem. Conclusion After 1 year the decrease in bone mineral density of the ankle on the affected limb was 9% and the contralateral ankle was close to baseline, thus suggesting that the periprosthetic bone mineral density changes during follow-up, mainly are caused by stress shielding and immobilization. Trial registration The study was approved by the Scientific Ethical Committee of the Capital Region of Denmark (J. No. H-2-2014-105) and the Danish Data Protection Agency (J. No.:2012–58-00004).

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Selecting regions of interest on intraoral radiographs for the prediction of bone mineral density

Dentomaxillofacial Radiology ◽

10.1259/dmfr/29966973 ◽

2008 ◽

Vol 37 (7) ◽

pp. 375-379 ◽

Cited By ~ 10

Author(s):

W G M Geraets ◽

J G C Verheij ◽

P F van der Stelt ◽

K Horner ◽

C Lindh ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Regions Of Interest ◽

Mineral Density

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Quantitative Measurements of Adaptive Bone Remodeling Around the Cemented Zimmer® Segmental Stem After Tumor Resection Arthroplasty Using Dual-energy x-ray absorptiometry

10.21203/rs.3.rs-23637/v1 ◽

2020 ◽

Author(s):

Christina Enciso Holm ◽

Peter Frederik Horstmann ◽

Michala Skovlund Sørensen ◽

Karen Dyreborg ◽

Michael Mørk Petersen

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Tumor Resection ◽

Regions Of Interest ◽

Trabecular Metal ◽

Mineral Density ◽

X Ray ◽

Tumor Prosthesis ◽

Cemented Stem

Abstract Background: Limb salvage surgery is the preferred method for treatment of patients with sarcomas and to a greater extent also to patients with metastatic bone disease. The aim of the present study was to evaluate the adaptive remodeling of the periprosthetic cortical bone after insertion of a tumor prosthesis with cemented stem. Methods :A prospective study of 21 patients (F/M=12/9), mean age 55 years (range 15-81) with metastatic bone disease (n=9), sarcomas (n=8) or aggressive benign tumors (n=4) who underwent bone tumor resection and reconstruction with a tumor-prosthesis (Zimmer® Segmental 130 mm straight fluted cemented stem with trabecular metal collars in the proximal femur (n=10), distal femur (n=9) or proximal tibia (n=2) . Measurements of bone mineral density (BMD) (g/cm 2 ) were done postoperatively and after 3, 6, and 12 months using dual-energy X-ray absorptiometry. BMD was measured in 4 regions of interest around the cemented stem and in one region of interest 1 cm proximal from the ankle joint of the affected limb and measurement of the contralateral ankle was used as reference. Repeated measures ANOVA and students paired t-test was used to evaluate BMD changes over time. Results: At 1-year follow-up, BMD decreased compared to baseline in all four regions of interest with a statistically significant bone loss of 8-15%. The bone loss was most pronounced (14-15%) in the 2 regions of interest closest to the trabecular metal collar and lowest (8%) adjacent to the tip of the stem. Conclusion: After one year the decrease in bone mineral density of the ankle on the affected limb was 9% and the contralateral ankle was close to baseline, thus suggesting that the periprosthetic bone mineral density changes during follow-up, mainly are caused by stress shielding and immobilization. Trial registration The study was approved by the Scientific Ethical Committee of the Capital Region of Denmark (J. No. H-2-2014-105) and the Danish Data Protection Agency (J. No.:2012-58-00004).

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