Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

2008 ◽  
Vol 97 (10) ◽  
pp. 4219-4227 ◽  
Author(s):  
Sonoko Kanai ◽  
Jun Liu ◽  
Thomas W. Patapoff ◽  
Steven J. Shire
Keyword(s):  
Monoclonal Antibody ◽  
Solution Viscosity ◽  
Self Association ◽  
Antibody Solution

scholarly journals Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction

2020 ◽  
Vol 109 (1) ◽  
pp. 443-451 ◽  
Author(s):  
Lorenzo Gentiluomo ◽  
Dierk Roessner ◽  
Werner Streicher ◽  
Sujata Mahapatra ◽  
Pernille Harris ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Self Association

Characterization of Subvisible Particle Formation During the Filling Pump Operation of a Monoclonal Antibody Solution

2011 ◽  
Vol 100 (10) ◽  
pp. 4198-4204 ◽  
Author(s):  
Arpan Nayak ◽  
James Colandene ◽  
Victor Bradford ◽  
Melissa Perkins
Keyword(s):  
Monoclonal Antibody ◽  
Particle Formation ◽  
Pump Operation ◽  
Antibody Solution

scholarly journals Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Claire L. Dobson ◽  
Paul W. A. Devine ◽  
Jonathan J. Phillips ◽  
Daniel R. Higazi ◽  
Christopher Lloyd ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Surface Properties ◽  
Human Monoclonal Antibody ◽  
Rapid Clearance ◽  
Self Association

scholarly journals Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

mAbs ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 941-950 ◽  
Author(s):  
James C. Geoghegan ◽  
Ryan Fleming ◽  
Melissa Damschroder ◽  
Steven M. Bishop ◽  
Hasige A. Sathish ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Rational Structure ◽  
Igg1 Monoclonal Antibody ◽  
Human Igg1 ◽  
Self Association ◽  
Human Igg1 Monoclonal Antibody
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