A Novel Flow through Diffusion Cell for Assessing Drug Transport across the Buccal Mucosa In Vitro

2009 ◽  
Vol 98 (12) ◽  
pp. 4577-4588 ◽  
Author(s):  
Maria L.A.D. Lestari ◽  
Joseph A. Nicolazzo ◽  
Barrie C. Finnin
Keyword(s):  
Buccal Mucosa ◽  
Drug Transport ◽  
Diffusion Cell ◽  
Flow Through ◽  
Through Diffusion

The flow-through diffusion cell (FTDC) method: a novel approach toin vitro drug release studies

2005 ◽  
Vol 55 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Sunil K Bajpai ◽  
Sutanjay Saxena ◽  
Seema Dubey
Keyword(s):  
Drug Release ◽  
Diffusion Cell ◽  
Novel Approach ◽  
Release Studies ◽  
Flow Through ◽  
Through Diffusion

scholarly journals Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 222 ◽  
Author(s):  
Alessandra Adrover ◽  
Gabriele Varani ◽  
Patrizia Paolicelli ◽  
Stefania Petralito ◽  
Laura Di Muzio ◽  
...  
Keyword(s):  
Thin Films ◽  
Drug Transport ◽  
Hydroxypropyl Methylcellulose ◽  
In Vitro Release ◽  
Franz Cell ◽  
Flow Through ◽  
Dissolution Apparatus ◽  
Model Drug ◽  
Drug Incorporation

In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the millifluidic flow-through device, and the paddle type dissolution apparatus (USP II). In order to enable drug incorporation within HPMC films, a multifunctional excipient, hydroxypropyl- β -cyclodextrin (HP- β -CD) has been included in the formulation, and the influence of HP- β -CD on film swelling, erosion, and release properties has been investigated. Mathematical models capable of describing the swelling and release processes from HPMC erodible thin films in different apparatuses have been developed. In particular, we propose a new model for the description of drug transport and release in a Franz cell that accounts for the effect of the unavoidable imperfect mixing of the receptor chamber.

Modifications of In Vitro Skin Penetration Under Solar Irradiation: Evaluation on Flow-through Diffusion Cells¶

2007 ◽  
Vol 75 (6) ◽  
pp. 598-604
Author(s):  
Christelle Gélis ◽  
Alain Mavon ◽  
Maxence Delverdier ◽  
Nicole Paillous ◽  
Patricia Vicendo
Keyword(s):  
Skin Penetration ◽  
Solar Irradiation ◽  
Diffusion Cells ◽  
Flow Through ◽  
Through Diffusion ◽  
In Vitro Skin Penetration
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