Development of High-Energy Amorphous Solid Dispersion of Nanosized Nobiletin, a Citrus Polymethoxylated Flavone, with Improved Oral Bioavailability

2011 ◽  
Vol 100 (9) ◽  
pp. 3793-3801 ◽  
Author(s):  
Satomi Onoue ◽  
Atsushi Uchida ◽  
Haruki Takahashi ◽  
Yoshiki Seto ◽  
Yohei Kawabata ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Amorphous Solid ◽  
High Energy ◽  
Amorphous Solid Dispersion

scholarly journals Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion

2020 ◽  
Vol 10 (5) ◽  
pp. 255-263
Author(s):  
Smruti P. Chaudhari ◽  
Mittal Bhadiyadra ◽  
Rutesh H. Dave
Keyword(s):  
Silicon Dioxide ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Water Solubility ◽  
High Surface ◽  
Amorphous Solid ◽  
Energy System ◽  
High Energy ◽  
Amorphous Solid Dispersion ◽  
The Stability

Advancement in the discovery of drugs has led to many highly lipophilic compounds with very low water solubility. Amorphous solid dispersion is one of the emerging technologies to increase the solubility of these drugs. The stability of these systems is critical since the high energy system tends to recrystallize, which negates the benefits of these systems. In this paper, we are evaluating the use of colloidal silicon dioxide as a potential stabilizer to stabilize the amorphous solid dispersions. Two types of colloidal silicon dioxide are used: porous colloidal silicon dioxide -Syloid 244 Fp and nonporous fumed silica – Aerosil 200. These silicon dioxides have a high surface area. Two methods of incorporation are used to incorporate silicon dioxide into the solid dispersion. The spray drying method is used to make amorphous solid dispersion. It was found that porous silicon dioxide is better to increase stability as well as increasing dissolution rate and % release of the drug. The addition of silicon dioxide internally to the dispersion increases the dissolution rate, and the addition of silicon dioxide externally increases the stability of the solid dispersion. Keywords: colloidal silicon dioxide, stabilizer, amorphous solid dispersion, low water solubility

Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach

2010 ◽  
Vol 399 (1-2) ◽  
pp. 94-101 ◽  
Author(s):  
Satomi Onoue ◽  
Hideyuki Sato ◽  
Kumiko Ogawa ◽  
Yohei Kawabata ◽  
Takahiro Mizumoto ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Cyclosporine A ◽  
Amorphous Solid ◽  
High Energy ◽  
Amorphous Solid Dispersion ◽  
Pharmacokinetic Behavior

Effect of supersaturation on the oral bioavailability of paclitaxel/polymer amorphous solid dispersion

2018 ◽  
Vol 9 (1) ◽  
pp. 344-356 ◽  
Author(s):  
Linlin Miao ◽  
Yuheng Liang ◽  
Wenli Pan ◽  
Jingxin Gou ◽  
Tian Yin ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion
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