Application of Mesoporous Silicon Dioxide and Silicate in Oral Amorphous Drug Delivery Systems

Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.

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On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2017.10.057 ◽

2018 ◽

Vol 535 (1-2) ◽

pp. 86-94 ◽

Cited By ~ 23

Author(s):

Wenqi Wu ◽

Korbinian Löbmann ◽

Thomas Rades ◽

Holger Grohganz

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Structural Similarity ◽

Delivery Systems ◽

Salt Formation ◽

Amorphous Drug

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Mesoporous silicon oxycarbide materials for controlled drug delivery systems

Chemical Engineering Journal ◽

10.1016/j.cej.2015.05.111 ◽

2015 ◽

Vol 280 ◽

pp. 165-174 ◽

Cited By ~ 28

Author(s):

Aitana Tamayo ◽

M. Alejandra Mazo ◽

Roberto Ruiz-Caro ◽

Araceli Martín-Illana ◽

Luis Miguel Bedoya ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Controlled Drug Delivery ◽

Delivery Systems ◽

Silicon Oxycarbide ◽

Mesoporous Silicon

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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