Preparation and Physicochemical Characterization of Acyclovir Cocrystals with Improved Dissolution Properties

2013 ◽  
Vol 102 (11) ◽  
pp. 4079-4086 ◽  
Author(s):  
Giovanna Bruni ◽  
Mariarosa Maietta ◽  
Lauretta Maggi ◽  
Piercarlo Mustarelli ◽  
Chiara Ferrara ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Dissolution Properties

Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000

2010 ◽  
Vol 3 (2) ◽  
pp. 948-956
Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Drug Carriers ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Peg 4000 ◽  
Release Studies ◽  
Crystalline Nature ◽  
Physical Mixtures

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.

scholarly journals Physicochemical Characterization of Febuxostat Microcomplexes with Parent and Modified Cyclodextrins

2018 ◽  
Vol 17 (1) ◽  
pp. 51-63
Author(s):  
Sayee V Aher ◽  
Yogesh V Pore
Keyword(s):  
Physicochemical Properties ◽  
Physicochemical Characterization ◽  
Log P ◽  
Phase Solubility ◽  
Solubility Curve ◽  
Drying Process ◽  
Linear Type ◽  
Modified Cyclodextrins ◽  
Dissolution Properties

Febuxostat, a BCS class II antigout drug was complexed with β-cyclodextrin (βCD), hydroxypropyl-β- cyclodextrin (HPβCD) and / or methyl-β-cyclodextrin (MβCD), to improve its physicochemical properties. Earlier phase solubility and thermodynamic investigations in acetate buffer (pH 4.5) illustrated AL (linear) type of solubility curve and enthalpy driven complexation process, respectively. The association constant and complexation efficiency of modified cyclodextrins (CDs) were significantly higher than that of parent cyclodextrin (CD). The microcomplexes prepared by spray drying process were examined for their spectral, diffractometric, thermal, particle size, saturation solubility, Log P and dissolution properties. The physicochemical properties of pure drug were improved upon complexation with CDs. However, modified CDs produced amorphous micro-complexes contributing for their better performance as compared to parent CD.Dhaka Univ. J. Pharm. Sci. 17(1): 51-63, 2018 (June)

Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide

2019 ◽  
Vol 9 (01) ◽  
pp. 21-26
Author(s):  
Arif Budiman ◽  
Ayu Apriliani ◽  
Tazyinul Qoriah ◽  
Sandra Megantara
Keyword(s):  
Solvent Evaporation ◽  
Physical Mixture ◽  
Dissolution Profile ◽  
Solvent Evaporation Method ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Evaporation Method ◽  
Dissolution Properties ◽  
Mixture Characterization

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture

Optimization and Physicochemical Characterization of Chitosan and Chitosan Nanoparticles Extracted from the Crayfish Procambarus clarkii Wastes

2019 ◽  
Vol 38 (2) ◽  
pp. 385 ◽  
Author(s):  
Marwa M. El-Naggar ◽  
Wael S. I. Abou-Elmagd ◽  
Ashraf Suloma ◽  
Hamza A. El-Shabaka ◽  
Magdy T. Khalil ◽  
...  
Keyword(s):  
Procambarus Clarkii ◽  
Chitosan Nanoparticles ◽  
Physicochemical Characterization

Purification and Physicochemical Characterization of a Trypsin Inhibitor from Cassia absus Linn

2013 ◽  
Vol 21 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Girijesh Patel ◽  
Amit Gupta ◽  
Akshita Gupta ◽  
Manisha Mishra ◽  
Pradhyumna Singh ◽  
...  
Keyword(s):  
Trypsin Inhibitor ◽  
Physicochemical Characterization

Physicochemical characterization of peptides and proteins by capillary electromigration methods

2005 ◽  
Author(s):  
Václav Kašička ◽  
Dušan Koval ◽  
Veronika Šolínová ◽  
Petra Sázelová ◽  
Zdeněk Prusík
Keyword(s):  
Physicochemical Characterization

scholarly journals Physicochemical characterization of ribosomal particles from the eukaryote Artemia.

1981 ◽  
Vol 256 (18) ◽  
pp. 9626-9632
Author(s):  
P. Nieuwenhuysen ◽  
J. Clauwaert
Keyword(s):  
Physicochemical Characterization
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