Machine Learning Enhanced Spectroscopic Analysis: Towards Autonomous Chemical Mixture Characterization for Rapid Process Optimization

Autonomous chemical process development and optimization methods use algorithms to explore the operating parameter space based on feedback from experimentally determined exit stream compositions. Measuring the compositions of multicomponent streams...

Microstrip coupled high sensitivity sensor for water ethanol mixture characterization

A multi spiral split ring resonator based sensor is proposed for the characterization of the dielectric properties of a water ethanol mixture. The use of a narrowed microstrip line to excite the multi spiral resonator allows enhancement of excitation current and increase the sensitivity of the sensing area. Good agreement will be presented between theoretical and measured electrical parameters of the resonator in a wide frequency range from 2 to 5 GHz. The proposed sensor shows high sensitivity, miniature size, and affordable cost and above all laboratory-on-chip compatibility important for a large-scale production.

Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture