Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000

2010 ◽  
Vol 3 (2) ◽  
pp. 948-956
Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Drug Carriers ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Peg 4000 ◽  
Release Studies ◽  
Crystalline Nature ◽  
Physical Mixtures

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.

Development and physicochemical characterization of saquinavir mesylate solid dispersions using Gelucire 44/14 or PEG 4000 as carrier

2013 ◽  
Vol 36 (9) ◽  
pp. 1113-1125 ◽  
Author(s):  
Thiago Caon ◽  
Ricardo Augusto Konig ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Simone Gonçalves Cardoso ◽  
Carlos Eduardo Maduro Campos ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Peg 4000

Design and Evaluation of Sustained Release Solid Dispersions of Verapamil Hydrochloride

2011 ◽  
Vol 3 (4) ◽  
pp. 1252-1262
Author(s):  
Swain S K ◽  
Niranjan Patra Patra ◽  
Sruti J ◽  
M.E. Bhanoji Rao
Keyword(s):  
Solid Dispersions ◽  
Verapamil Hydrochloride ◽  
Ir Studies ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Release Studies ◽  
Ft Ir ◽  
Mechanism And Kinetics ◽  
Model Drug ◽  
Kinetics Of

The Purpose of this study was to prepare and characterize solid dispersions of this antiarrhythmic drug Verapamil hydrochloride (VPH) with HPMCK4M, EudragitRSPO and their combination with a view to sustain its dissolution properties. Investigation of the properties of the prepared solid dispersions were performed using release studies and Fourier transform infrared (FT-IR). The results obtained showed that the rate of dissolution of Verapamil hydrochloride was considerably more sustained when formulated in solid dispersions with HPMCK4M and Eudragit RSPO as compared with pure drug and physical mixtures. FT-IR studies confirmed absence of any possible solid state drug and polymer interactions. In order to establish the mechanism and kinetics of drug release, the experimental data was fitted to different kinetic models likes zero order, first order, Higuchi’s model, korsmeyer peppa’s model. From the above research it may be concluded that HPMCK4M acts as a better release retardant for the model drug.

Physicochemical characterization of dipeptidyl peptidase-4 inhibitor alogliptin in physical mixtures with excipients

2017 ◽  
Vol 130 (3) ◽  
pp. 1575-1584 ◽  
Author(s):  
Charise Dallazem Bertol ◽  
Rafael Nicolay Pereira ◽  
Cassiana Mendes ◽  
Amarilis Scremim Paulino ◽  
Marcos Antônio Segatto Silva ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitor ◽  
Physical Mixtures

Preparation and Physicochemical Characterization of Acyclovir Cocrystals with Improved Dissolution Properties

2013 ◽  
Vol 102 (11) ◽  
pp. 4079-4086 ◽  
Author(s):  
Giovanna Bruni ◽  
Mariarosa Maietta ◽  
Lauretta Maggi ◽  
Piercarlo Mustarelli ◽  
Chiara Ferrara ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Dissolution Properties

scholarly journals Preparation and Characterization of Stealth Archaeosomes Based on a Synthetic PEGylated Archaeal Tetraether Lipid

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Julie Barbeau ◽  
Sandrine Cammas-Marion ◽  
Pierrick Auvray ◽  
Thierry Benvegnu
Keyword(s):  
High Performance ◽  
Drug Carriers ◽  
Physicochemical Characteristics ◽  
Release Studies ◽  
Poly Ethylene ◽  
Membrane Spanning ◽  
The Stability ◽  
The One ◽  
Egg Pc

The present studies were focused on the formation and characterization of sterically stabilized archaeosomes made from a synthetic PEGylated archaeal lipid. In a first step, a synthetic archaeal tetraether bipolar lipid was functionalized with a poly(ethylene glycol), PEG, and (PEG45-Tetraether) with the aim of coating the archaeosome surface with a sterically stabilizing hydrophilic polymer. In a second step, Egg-PC/PEG45-Tetraether (90/10 wt%) archaeosomes were prepared, and their physicochemical characteristics were determined by dynamic light scattering (size, polydispersity), cryo-TEM (morphology), and by high-performance thin layer chromatography (lipid composition), in comparison with standard Egg-PC/PEG45-DSPE formulations. Further, a fluorescent dye, the carboxyfluorescein, was encapsulated into the prepared archaeosomes in order to evaluate the potential of such nanostructures as drug carriers. Release studies have shown that the stability of Egg-PC/PEG45-Tetraether-based archaeosomes is significantly higher at 37∘C than the one of Egg-PC/PEG45-DSPE-based liposomes, as evidenced by the slower release of the dye encapsulated into PEGylated archaeosomes. This enhanced stability could be related to the membrane spanning properties of the archaeal bipolar lipid as already described with natural or synthetic tetraether lipids.

Physicochemical characterization of atorvastatin calcium/ezetimibe amorphous nano-solid dispersions prepared by electrospraying method

2016 ◽  
Vol 45 (6) ◽  
pp. 1138-1145 ◽  
Author(s):  
Azin Jahangiri ◽  
Mohammad Barzegar-Jalali ◽  
Yousef Javadzadeh ◽  
Hamed Hamishehkar ◽  
Khosro Adibkia
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Atorvastatin Calcium

scholarly journals EFFECT OF CARRIER TYPES ON THE PHYSICOCHEMICAL AND DISSOLUTION CHARACTERISTICS OF OFLOXACIN SOLID DISPERSION

2002 ◽  
Vol 70 (3) ◽  
pp. 309-316
Author(s):  
Okonogi S ◽  
Sirithunyalung J ◽  
Sirithunyalig B ◽  
Wolschann P ◽  
Viernstein H
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Weight Fraction ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Dissolution Enhancement ◽  
Water Soluble Polymers ◽  
Dissolution Properties ◽  
Peg 4000

Solid dispersions of ofloxacin (OFX) and of a number of carriers including chitosan and the water soluble polymers polyethylene glycol (PEG) 4000, PEG 20000, and polyvinylpyrrolidone K- 90 were prepared by solvent evaporation method in order to increase the dissolution of the drug. The solid dispersions were subjected to X-ray diffraction, DSC, and dissolution to characterize their physicochemical and dissolution properties. The results demonstrated a decrease in drug crystallinity at higher amounts of carrier. Dissolution studies indicated that the dissolution rate of OFX was markedly increased in these solid dispersion systems compared with the pure drug. The results also showed that the increase in dissolution rate was higher when the weight fraction of carriers increased. An influence of molecular weight of PEG on OFX dissolution could also be observed. In solid dispersion with 1:9 ratio drug to carrier, PEG 4000 gave highest drug dissolution rate, whereas in 1:1 ratio, chitosan seems to be the best carrier for drug release. It was concluded that chitosan might be the carrier of choice for dissolution enhancement in solid dispersions with high content of drug.

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