An efficient strategy based on two‐stage chromatography and in vitro evaluation for rapid screening and isolation of acetylcholinesterase inhibitors from Scutellaria baicalensis Georgi

2022 ◽  
Author(s):  
Wanchao Hou ◽  
Chunming Liu ◽  
Sainan Li ◽  
Yuchi Zhang ◽  
Yongri Jin ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Scutellaria Baicalensis ◽  
Rapid Screening ◽  
Two Stage ◽  
In Vitro Evaluation ◽  
Scutellaria Baicalensis Georgi ◽  
Efficient Strategy

scholarly journals In vitro antibacterial activities of Scutellaria baicalensis Georgi against cariogenic bacterial

2007 ◽  
Vol 17 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Chunyan Duan ◽  
Seishi Matsumura ◽  
Naoyuki Kariya ◽  
Michiko Nishimura ◽  
Tsutomu Shimono
Keyword(s):  
Antibacterial Activities ◽  
Scutellaria Baicalensis ◽  
Scutellaria Baicalensis Georgi

The Stimulatory Activities of Baicalein and Baicalin Compounds Derived from Scutellaria baicalensis on Insulin Secretion In Vitro

2012 ◽  
Vol 554-556 ◽  
pp. 1673-1677 ◽  
Author(s):  
Yu Ping Li ◽  
Hu Su ◽  
Xiao Fang Pi ◽  
Yan Chun Gong ◽  
Xiang Yuan Xiong ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Total Cholesterol Level ◽  
Scutellaria Baicalensis ◽  
Dependent Manner ◽  
Scutellaria Baicalensis Georgi ◽  
Stimulatory Activity ◽  
Atp Levels ◽  
Glucose Stimulated Insulin Secretion ◽  
Insulin Secretion In Vitro

The medicinal plant Scutellaria baicalensis Georgi has been used widely in traditional Chinese medicine for anti-inflammation, anticancer, antiviral and antibacterial infections, reducing the total cholesterol level and decreasing blood pressures. Baicalein and baicalin are two major flavonoid of Scutellaria baicalensis Georgi, exhibit various bioactivities. In the present study, the stimulatory activity of baicalin and baicalein derived from Scutellaria baicalensis on insulin secretion in vitro was investigated using HIT-T15 cell, a Syrian hamster transformed β-cell line. The survival rate of cells treated with baicalin or baicalein (0.01-0.5 mg/ml) increased significantly (P < 0.05). In the presence of 5.6 mM glucose, baicalin or baicalein (0.01-0.5 mg/ml) increased glucose-stimulated insulin secretion and cellular ATP levels in HIT-T15 cells. Baicalin and baicalein exhibited significant stimulatory activity in a dose-dependent manner without apparent cytotoxicity at concentrations less than 0.1 mg/ml. The results obtained in this study suggest that baicalin or baicalein increases the insulin secretion of HIT-T15 cells by the enhancement of β-cells activity and cellular ATP levels. Baicalin or baicalein could be candidates for a new class of anti-diabetic drugs.

UPLC-Q-TOF/MS for Analysis of the Metabolites of Flavone Glycosides from Scutellaria baicalensis Georgi by Human Fecal Flora in Vitro

2013 ◽  
Vol 76 (15-16) ◽  
pp. 975-983 ◽  
Author(s):  
Jun Xu ◽  
Dawei Qian ◽  
Shu Jiang ◽  
Jianming Guo ◽  
Er-xin Shang ◽  
...  
Keyword(s):  
Scutellaria Baicalensis ◽  
Fecal Flora ◽  
Scutellaria Baicalensis Georgi ◽  
Flavone Glycosides ◽  
Tof Ms

Physiologically Active Flavones Content in Scutellaria baicalensis Georgi in vitro Cultures

2017 ◽  
pp. 29-37 ◽  
Author(s):  
A.V. Olina ◽  
◽  
A.I. Solovyova ◽  
A.E. Solovchenko ◽  
A.V. Orlova ◽  
...  
Keyword(s):  
In Vitro Cultures ◽  
Scutellaria Baicalensis ◽  
Scutellaria Baicalensis Georgi

In vitro effects of aqueous extracts of Astragalus membranaceus and Scutellaria baicalensis GEORGI on Toxoplasma gondii

2011 ◽  
Vol 110 (6) ◽  
pp. 2221-2227 ◽  
Author(s):  
Xiaoyan Yang ◽  
Bo Huang ◽  
Jianping Chen ◽  
Shiguang Huang ◽  
Huanqin Zheng ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Scutellaria Baicalensis ◽  
Astragalus Membranaceus ◽  
Aqueous Extracts ◽  
Scutellaria Baicalensis Georgi ◽  
In Vitro Effects
Sign in / Sign up

Export Citation Format

Share Document