Increased risk of getting sudden sensorineural hearing loss in patients with chronic kidney disease: A population-based cohort study

2012 ◽  
Vol 123 (3) ◽  
pp. 767-773 ◽  
Author(s):  
Charlene Lin ◽  
Hsin-Te Hsu ◽  
Yung-Song Lin ◽  
Shih-Feng Weng
Keyword(s):  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Cohort Study ◽  
Kidney Disease ◽  
Sensorineural Hearing Loss ◽  
Population Based ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Increased Risk

Increased risk of sudden sensorineural hearing loss in patients with depressive disorders: population-based cohort study

2015 ◽  
Vol 130 (1) ◽  
pp. 42-49 ◽  
Author(s):  
C-S Lin ◽  
Y-S Lin ◽  
C-F Liu ◽  
S-F Weng ◽  
C Lin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Kidney Disease ◽  
Sensorineural Hearing Loss ◽  
Depressive Disorders ◽  
Sudden Sensorineural Hearing Loss ◽  
Hazard Ratio ◽  
Sensorineural Hearing ◽  
Increased Risk

AbstractObjectives:To evaluate the incidence rates and risk of sudden sensorineural hearing loss among patients with depressive disorders.Method:Data for 27 547 patients with newly diagnosed depressive disorders and 27 547 subjects without depressive disorders between 2001 and 2008 were yielded from the Taiwan National Health Insurance Research Database. Sudden sensorineural hearing loss incidence at the end of 2011 was determined. Cumulative incidence and adjusted hazard ratio were computed.Results:Sudden sensorineural hearing loss incidence was 1.45 times higher in the depressive disorders group compared to the non-depressive disorders group (p = 0.0041), with an adjusted hazard ratio of 1.460. A significant increased risk of developing sudden sensorineural hearing loss was noted in patients with diabetes mellitus, chronic kidney disease and hyperlipidaemia (p < 0.05).Conclusion:The results suggest an increased risk of developing sudden sensorineural hearing loss in patients with depressive disorders. Co-morbidities such as diabetes mellitus, chronic kidney disease and hyperlipidaemia significantly aggravated the risk. Depressive disorders might be considered a risk factor for sudden sensorineural hearing loss. It remains to be seen whether control of depressive disorders can decrease the incidence of sudden sensorineural hearing loss in patients with depressive disorders.

Antidepressants and risk of sudden sensorineural hearing loss: a population-based cohort study

2021 ◽  
Author(s):  
Pei-Xun Zhong ◽  
I-Hsun Li ◽  
Jui-Hu Shih ◽  
Chin-Bin Yeh ◽  
Kuan-Wei Chiang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cohort Study ◽  
Sensorineural Hearing Loss ◽  
Animal Studies ◽  
Population Based ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Full Cohort ◽  
Increased Risk ◽  
Antidepressant Use

Abstract Background Increasing numbers of animal studies have found that sudden sensorineural hearing loss (SSNHL) is related to the mechanism of serotonergic modulation. However, the relationship between antidepressants and SSNHL is unclear in humans. Therefore, this study aimed to evaluate the association between antidepressant use and risk of SSNHL. Methods Data from 218 466 antidepressant users and 1 116 518 nonusers were obtained from the Taiwan Longitudinal Health Insurance Database. We used propensity-score matching (PSM) and inverse-probability treatment weighting (IPTW) to eliminate any bias. Each patient was tracked for 5 years to ascertain whether or not they were diagnosed with SSNHL. Cox proportional-hazard regression analyses were performed to calculate the SSNHL risk. Results The adjusted hazard ratio (aHR) of SSNHL for antidepressant users was 1.36 compared with nonusers in the full cohort study. The aHR for antidepressant users was 1.44 and 1.49 compared with the nonusers in the IPTW and PSM cohorts, respectively. All classes of antidepressants consistently increased the SSNHL risk. Additionally, patients receiving four classes of antidepressants were associated with a much higher SSNHL risk (aHR, 2.05) and those receiving one or two classes of antidepressants had a relatively lower SSNHL risk. Conclusion Antidepressants increased SSNHL risk, regardless of their class. Furthermore, patients who took a higher number of antidepressant classes showed an increased risk of developing SSNHL than those who took a lower number of antidepressant classes. Therefore, physicians should estimate the risks and benefits of antidepressant use and avoid prescribing antidepressants concurrently.

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