Predictors of outcomes in large cell undifferentiated carcinoma of the major salivary glands

2016 ◽  
Vol 127 (2) ◽  
pp. 372-376 ◽  
Author(s):  
Travis P. Schrank ◽  
Kevin Y. Zhan ◽  
Eric J. Lentsch
Keyword(s):  
Salivary Glands ◽  
Large Cell ◽  
Undifferentiated Carcinoma ◽  
Major Salivary Glands ◽  
Predictors Of Outcomes

scholarly journals Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands

Cancer ◽  
2004 ◽  
Vol 101 (9) ◽  
pp. 2020-2027 ◽  
Author(s):  
Cheng-Ping Wang ◽  
Yih-Leong Chang ◽  
Jenq-Yuh Ko ◽  
Pei-Jen Lou ◽  
Chun-Fong Yeh ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Large Cell ◽  
Undifferentiated Carcinoma ◽  
Lymphoepithelial Carcinoma ◽  
Major Salivary Glands

scholarly journals Undifferentiated carcinoma of the major salivary glands

Cancer ◽  
1997 ◽  
Vol 80 (3) ◽  
pp. 357-363 ◽  
Author(s):  
Tzung-Shiahn Sheen ◽  
Chien-Chen Tsai ◽  
Jenq-Yuh Ko ◽  
Yang-Liang Chang ◽  
Mow-Ming Hsu
Keyword(s):  
Salivary Glands ◽  
Undifferentiated Carcinoma ◽  
Major Salivary Glands

Undifferentiated Carcinoma with Lymphoid Stroma of the Major Salivary Glands

1990 ◽  
Vol 99 (3) ◽  
pp. 236-238 ◽  
Author(s):  
Karen R. Cleary ◽  
John G. Batsakis
Keyword(s):  
Salivary Glands ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Response To Therapy ◽  
Lymphoepithelial Carcinoma ◽  
Lymphoepithelial Lesion ◽  
Barr Virus ◽  
Lymphoid Stroma ◽  
Major Salivary Glands ◽  
Epstein Barr

Undifferentiated carcinoma with lymphoid stroma or lymphoepithelial carcinoma of the major salivary glands is a demographically and histopathologically unique malignancy. Although whites may have the disease, it is preponderantly a carcinoma of North American Eskimos and native Greenlanders. The carcinoma shares many features with undifferentiated nasopharyngeal carcinomas, from which it must be distinguished: histologic appearance, putative relationship with Epstein-Barr virus, predilection for mongoloid races, and response to therapy. In some cases, the carcinoma appears to have evolved from a lymphoepithelial lesion.

scholarly journals Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1073 ◽  
Author(s):  
Rodolfo Montironi ◽  
Alessia Cimadamore ◽  
Antonio Lopez-Beltran ◽  
Marina Scarpelli ◽  
Gaetano Aurilio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Final Diagnosis ◽  
Undifferentiated Carcinoma ◽  
Castration Resistant Prostate Cancer ◽  
Platinum Based Chemotherapy ◽  
Intermediate Part ◽  
Aggressive Variant

The term aggressive variant prostate cancer (AVPCa) refers to androgen receptor (AR)-independent anaplastic forms of prostate cancer (PCa), clinically characterized by a rapidly progressive disease course. This involves hormone refractoriness and metastasis in visceral sites. Morphologically, AVPCa is made up of solid sheets of cells devoid of pleomorphism, with round and enlarged nuclei with prominent nucleoli and slightly basophilic cytoplasm. The cells do not show the typical architectural features of prostatic adenocarcinoma and mimic the undifferentiated carcinoma of other organs and locations. The final diagnosis is based on the immunohistochemical expression of markers usually seen in the prostate, such as prostate-specific membrane antigen (PSMA). A subset of AVPCa can also express neuroendocrine (NE) markers such as chromogranin A, synaptophysin and CD56. This letter subset represents an intermediate part of the spectrum of NE tumors which ranges from small cell to large cell carcinoma. All such tumors can develop following potent androgen receptor pathway inhibition. This means that castration-resistant prostate cancer (CRPCa) transdifferentiates and becomes a treatment-related NE PCa in a clonally divergent manner. The tumors that do not show NE differentiation might harbor somatic and/or germline alterations in the DNA repair pathway. The identification of these subtypes has direct clinical relevance with regard to the potential benefit of platinum-based chemotherapy, poly (ADP-ribose) polymerase inhibitors and likely further therapies.

Mucoepidermoid tumors of the major salivary glands

1971 ◽  
Vol 48 (2) ◽  
pp. 199-200
Author(s):  
S E Tharvaldsson ◽  
O H Beahrs ◽  
L B Woolner ◽  
J B Simons
Keyword(s):  
Salivary Glands ◽  
Major Salivary Glands
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