Impact of Cationic Charge Density and PEGylated Poly(Amino Acid) Tercopolymer Architecture on Their Use as Gene Delivery Vehicles. Part 2: DNA Protection, Stability, Cytotoxicity, and Transfection Efficiency

2018 ◽  
Vol 18 (8) ◽  
pp. 1800109 ◽  
Author(s):  
David Ulkoski ◽  
Carmen Scholz
Keyword(s):  
Amino Acid ◽  
Gene Delivery ◽  
Charge Density ◽  
Transfection Efficiency ◽  
Dna Protection ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles

2015 ◽  
Vol 3 (13) ◽  
pp. 2660-2670 ◽  
Author(s):  
Qian Guo ◽  
Yan-Hong Liu ◽  
Miao-Miao Xun ◽  
Ji Zhang ◽  
Zheng Huang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Glycidyl Ether ◽  
Ring Opening Polymerization ◽  
Low Molecular Weight ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

PEI 600-based polymers were synthesized via ring-opening polymerization and exhibited much better transfection efficiency and biocompatibility than PEI 25 kDa.

Bio-reducible polycations from ring-opening polymerization as potential gene delivery vehicles

2016 ◽  
Vol 14 (27) ◽  
pp. 6470-6478 ◽  
Author(s):  
Qing-Ying Yu ◽  
Yan-Hong Liu ◽  
Zheng Huang ◽  
Ji Zhang ◽  
Chao-Ran Luan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Ring Opening Polymerization ◽  
Dna Condensation ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

Bio-reducible polycations were prepared via ring-opening polymerization. These materials have relatively low molecular weights and cytotoxicity but have good DNA condensation ability, transfection efficiency and excellent serum tolerance.

Characterization of Cationic Vector-Based Gene Delivery Vehicles Using Isothermal Titration and Differential Scanning Calorimetry

2003 ◽  
pp. 319-348 ◽  
Author(s):  
Brian A. Lobo ◽  
Sheila A. Rogers ◽  
Christopher M. Wiethoff ◽  
Sirirat Choosakoonkriang ◽  
Susan Bogdanowich-Knipp ◽  
...  
Keyword(s):  
Differential Scanning Calorimetry ◽  
Gene Delivery ◽  
Scanning Calorimetry ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

scholarly journals Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy

2018 ◽  
Vol 2 (4) ◽  
pp. 371-386 ◽  
Author(s):  
Feng Yin ◽  
Tommy Anderson ◽  
Nishtha Panwar ◽  
Kang Zhang ◽  
Swee Chuan Tjin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Gene Delivery ◽  
Mos2 Nanosheets ◽  
Delivery Vehicles ◽  
Pancreatic Cancer Therapy ◽  
Gene Delivery Vehicles

A multifunctional polymeric gene delivery system for circumventing biological barriers

2019 ◽  
Vol 7 (3) ◽  
pp. 384-392 ◽  
Author(s):  
Huajie Zhu ◽  
Jinxia An ◽  
Chengcai Pang ◽  
Shuai Chen ◽  
Wei Li ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Triblock Copolymer ◽  
Gene Delivery System ◽  
Biological Barriers ◽  
Stimulus Responsive ◽  
Polymeric Gene Delivery ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

Crucial light-controlled-ROS and pH-stimulus-responsive functionalities are tailored into a triblock copolymer for manufacture of gene delivery vehicles.

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