Biodegradable Porous Microneedles for an Electric Skin Patch

2021 ◽  
Vol 306 (9) ◽  
pp. 2170033
Author(s):  
Hiroya Abe ◽  
Yuuya Matsui ◽  
Natsumi Kimura ◽  
Matsuhiko Nishizawa
Keyword(s):  
1998 ◽  
Vol 139 (5) ◽  
pp. 938-939 ◽  
Author(s):  
Chung ◽  
Bang ◽  
Lee ◽  
Sung ◽  
Park ◽  
...  

Author(s):  
Changhyun Pang ◽  
Chanseok Lee ◽  
Hoon Eui Jeong ◽  
Kahp-Yang Suh

Close observation of various attachment systems in animal skins has revealed various exquisite multi-scale architectures for essential functions such as locomotion, crawling, mating, and protection from predators. Some of these adhesion systems of geckos and beetles have unique structural features (e.g. high-aspect ratio, tilted angle, and hierarchical nanostructure), resulting in mechanical interlocking mediated by van der Waals forces or liquid secretion (capillary force). In this chapter, we present an overview of recent advances in bio-inspired, artificial dry adhesives, and biomimetics in the context of nanofabrication and material properties. In addition, relevant bio-inspired structural materials, devices (clean transportation device, interlocker, biomedical skin patch, and flexible strain-gauge sensor) and microrobots are briefly introduced, which would shed light on future smart, directional, and reversible adhesion systems.


Nano Energy ◽  
2021 ◽  
pp. 106156
Author(s):  
Min Hyouk Kim ◽  
Chang Hee Cho ◽  
Jun Su Kim ◽  
Tae Uk Nam ◽  
Woo-Sik Kim ◽  
...  

2012 ◽  
Vol 125 (12) ◽  
pp. e1-e2 ◽  
Author(s):  
Antoine Néel ◽  
Muriel Hello ◽  
Sebastien Barbarot ◽  
Frédérique Jossic ◽  
Agathe Masseau ◽  
...  
Keyword(s):  

2021 ◽  
Vol 2021.56 (0) ◽  
pp. 133_paper
Author(s):  
Kaito SATO ◽  
Shinya KUSAMA ◽  
Yuya Matsui ◽  
Natsumi KIMURA ◽  
Hiroya ABE ◽  
...  

Vaccine ◽  
2015 ◽  
Vol 33 (48) ◽  
pp. 6675-6683 ◽  
Author(s):  
Frances E. Pearson ◽  
David A. Muller ◽  
Lucy Roalfe ◽  
Marta Zancolli ◽  
David Goldblatt ◽  
...  

2017 ◽  
Vol 103 (4) ◽  
pp. 371-376 ◽  
Author(s):  
Jeremy R Parr ◽  
Emma Todhunter ◽  
Lindsay Pennington ◽  
Deborah Stocken ◽  
Jill Cadwgan ◽  
...  

ObjectiveInvestigate whether hyoscine patch or glycopyrronium liquid is more effective and acceptable to treat drooling in children with neurodisability.DesignMulticentre, single-blind, randomised controlled trial.SettingRecruitment through neurodisability teams; treatment by parents.ParticipantsNinety children with neurodisability who had never received medication for drooling (55 boys, 35 girls; median age 4 years). Exclusion criteria: medication contraindicated; in a trial that could affect drooling or management.InterventionChildren were randomised to receive a hyoscine skin patch or glycopyrronium liquid. Dose was increased over 4 weeks to achieve optimum symptom control with minimal side-effects; steady dose then continued to 12 weeks.Primary and secondary outcomesPrimary outcome: Drooling Impact Scale (DIS) score at week-4. Secondary outcomes: change in DIS scores over 12 weeks, Drooling Severity and Frequency Scale and Treatment Satisfaction Questionnaire for Medication; adverse events; children’s perception about treatment.ResultsBoth medications yielded clinically and statistically significant reductions in mean DIS at week-4 (25.0 (SD 22.2) for hyoscine and 26.6 (SD 16) for glycopyrronium). There was no significant difference in change in DIS scores between treatment groups. By week-12, 26/47 (55%) children starting treatment were receiving hyoscine compared with 31/38 (82%) on glycopyrronium. There was a 42% increased chance of being on treatment at week-12 for children randomised to glycopyrronium relative to hyoscine (1.42, 95% CI 1.04 to 1.95).ConclusionsHyoscine and glycopyrronium are clinically effective in treating drooling in children with neurodisability. Hyoscine produced more problematic side effects leading to a greater chance of treatment cessation.Trial registration numbersISRCTN75287237; EUDRACT: 2013-000863-94; Medicines and Healthcare Products Regulatory Agency: 17136/0264/001-0003


2020 ◽  
Vol 166 ◽  
pp. 108491 ◽  
Author(s):  
Ali Pashazadeh ◽  
Eduardo de Paiva ◽  
Naghmeh Mahmoodian ◽  
Michael Friebe

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