The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001

2012 ◽  
Vol 52 (6) ◽  
pp. 446-458 ◽  
Author(s):  
Rebecca E. De Angel ◽  
Claudio J. Conti ◽  
Karrie E. Wheatley ◽  
Andrew J. Brenner ◽  
Glen Otto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Tumor Growth ◽  
Mammary Tumor ◽  
Mtor Pathway ◽  
Pathway Activation ◽  
Mammary Tumor Growth

scholarly journals Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 853
Author(s):  
Lengyun Wei ◽  
Xuyang Lu ◽  
Shengmei Weng ◽  
Shenglong Zhu ◽  
Yongquan Chen
Keyword(s):  
Tumor Growth ◽  
Cholesteryl Ester ◽  
Tumor Progression ◽  
Mammary Tumor ◽  
Causal Effect ◽  
Mtor Pathway ◽  
Breast Tumor Cell ◽  
Mammary Tumor Growth ◽  
Mammary Tumor Progression ◽  
Mcf 7

The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data suggest that SOAT1, a sterol O-acyltransferase, may be a potential target for the treatment of breast cancer.

scholarly journals Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1

2015 ◽  
Vol 97 (5) ◽  
pp. 929-940 ◽  
Author(s):  
Stephania Libreros ◽  
Ramon Garcia-Areas ◽  
Patricia Keating ◽  
Nathalia Gazaniga ◽  
Philip Robinson ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Mammary Tumor ◽  
Pulmonary Inflammation ◽  
Mammary Tumor Growth ◽  
Tumor Growth And Metastasis

Influence of lithium on mammary tumor growth in vivo

1980 ◽  
Vol 9 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Marina Ziche ◽  
Antonino Maiorana ◽  
Takami Oka ◽  
Pietro M. Gullino
Keyword(s):  
Tumor Growth ◽  
Mammary Tumor ◽  
Mammary Tumor Growth
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