A rohitukine derivative IIIM‐290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells

2021 ◽  
Author(s):  
Mubashir Mintoo ◽  
Sameer Khan ◽  
Abubakar Wani ◽  
Sumera Malik ◽  
Deendyal Bhurta ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Mitochondrial Apoptosis

scholarly journals Inhibition of Autophagy Enhances the Antitumor Effect of Thioridazine in Acute Lymphoblastic Leukemia Cells

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 365
Author(s):  
Carina Colturato-Kido ◽  
Rayssa M. Lopes ◽  
Hyllana C. D. Medeiros ◽  
Claudia A. Costa ◽  
Laura F. L. Prado-Souza ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Clinical Problem ◽  
Jurkat Cells ◽  
Leukemia Cells ◽  
Peripheral Mononuclear Blood ◽  
Induced Apoptosis ◽  
Cure Rates

Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the development of new therapeutic strategies and drugs to improve the disease outcome. Antipsychotic phenothiazines have emerged as potential candidates to be repositioned as antitumor drugs. It was previously shown that the anti-histaminic phenothiazine derivative promethazine induced autophagy-associated cell death in chronic myeloid leukemia cells, although autophagy can act as a “double-edged sword” contributing to cell survival or cell death. Here we evaluated the role of autophagy in thioridazine (TR)-induced cell death in the human ALL model. TR induced apoptosis in ALL Jurkat cells and it was not cytotoxic to normal peripheral mononuclear blood cells. TR promoted the activation of caspase-8 and -3, which was associated with increased NOXA/MCL-1 ratio and autophagy triggering. AMPK/PI3K/AKT/mTOR and MAPK/ERK pathways are involved in TR-induced cell death. The inhibition of the autophagic process enhanced the cytotoxicity of TR in Jurkat cells, highlighting autophagy as a targetable process for drug development purposes in ALL.

Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells

APOPTOSIS ◽  
2010 ◽  
Vol 15 (10) ◽  
pp. 1256-1269 ◽  
Author(s):  
Eun-Sil Sung ◽  
Aeyung Kim ◽  
Joon Seong Park ◽  
Junho Chung ◽  
Myung-Hee Kwon ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Histone Deacetylase Inhibitors ◽  
Apoptotic Cell ◽  
Lymphoblastic Leukemia ◽  
Death Receptor ◽  
Leukemia Cells ◽  
Human T Cell ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Death Receptor 4

Physcion blocks cell cycle and induces apoptosis in human B cell precursor acute lymphoblastic leukemia cells by downregulating HOXA5

2017 ◽  
Vol 94 ◽  
pp. 850-857 ◽  
Author(s):  
Fei Gao ◽  
Wenjun Liu ◽  
Qulian Guo ◽  
Yongqi Bai ◽  
Hong Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Cell Precursor ◽  
Human B Cell

scholarly journals STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)–STAT3 pathway

2016 ◽  
Vol 57 (11) ◽  
pp. 2681-2684 ◽  
Author(s):  
Amy Belton ◽  
Lingling Xian ◽  
Tait Huso ◽  
Michael Koo ◽  
Li Z. Luo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Antitumor Activity ◽  
Lymphoblastic Leukemia ◽  
High Mobility ◽  
High Mobility Group ◽  
Leukemia Cells ◽  
Stat3 Pathway ◽  
B Lineage

scholarly journals MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM

Leukemia ◽  
2009 ◽  
Vol 23 (10) ◽  
pp. 1744-1754 ◽  
Author(s):  
A A Rambal ◽  
Z L G Panaguiton ◽  
L Kramer ◽  
S Grant ◽  
H Harada
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Mek Inhibitors

Cytarabine and EIP co-administration synergistically reduces viability of acute lymphoblastic leukemia cells with high ERG expression

2021 ◽  
pp. 106649
Author(s):  
Liyan Cheng ◽  
Shenxin Zeng ◽  
Dongmei Yan ◽  
Linglan Tu ◽  
Yadong Yang ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells

Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture

1991 ◽  
Vol 15 (11) ◽  
pp. 1059-1066 ◽  
Author(s):  
Yasuhiko Kano ◽  
Shinobu Sakamoto ◽  
Tadashi Kasahara ◽  
Miyuki Akutsu ◽  
Yoshiharu Inoue ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Anticancer Agents ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Cells In Culture ◽  
Human Acute Lymphoblastic Leukemia

scholarly journals 3D/4D multiscale imaging in acute lymphoblastic leukemia cells-visualizing dynamics of cell death

2017 ◽  
Author(s):  
Sreelatha Sarangapani ◽  
Rosmin Elsa Mohan ◽  
Ajeetkumar Patil ◽  
Matthew J. Lang ◽  
Anand Asundi
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Multiscale Imaging
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